Copper-62-pyruvaldehyde bis(N4-methyl-thiosemicarbazone) PET imaging in the detection of coronary artery disease in humans

Thomas R. Wallhaus, Jeffrey Lacy, Richard Stewart, Jesus Bianco, Mark A. Green, Nisha Nayak, Charles K. Stone

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Background. Copper-62 (II)-pyruvaldehyde bis(N4-methyl-thiosemicarbazone) (PTSM) has been proposed for cardiac imaging with positron emission tomography (PET). This study evaluated the agreement between Cu-62-PTSM and coronary angiography in the detection of occlusive coronary artery disease. The normalcy rate for Cu-62-PTSM PET in a group of healthy volunteers was also assessed. Methods and Results. Forty-five subjects completed the study. Twenty-eight patients underwent stress technetium-99m sestamibi single photon emission computed tomography (SPECT) imaging and cardiac catheterization followed by Cu-62-PTSM rest/dipyridamole stress PET scans, and 17 volunteers underwent Cu-62-PTSM rest/dipyridamole stress PET scans. Cu-62- PTSM myocardial perfusion defects were identified in 100% of patients with 3-vessel disease (n=8), 100% of patients with 2-vessel disease (n=9), and 67% of patients with single-vessel disease (n=6). When considering individual vessels, Cu-62-PTSM perfusion defects were seen in 72% of patients with occlusive disease in the left anterior descending artery territory, 67% in the left circumflex artery territory, and 60% in the right coronary artery territory, respectively. All 17 healthy volunteers had Cu-62-PTSM scans interpreted as normal, for a normalcy rate of 100%. Conclusions. Perfusion abnormalities are demonstrated by means of Cu-62-PTSM PET in 91% of patients with occlusive coronary artery disease seen at the time of cardiac catheterization, and it shows an excellent normalcy rate of 100%.

Original languageEnglish (US)
Pages (from-to)67-74
Number of pages8
JournalJournal of Nuclear Cardiology
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Keywords

  • Copper-62 (II)-pyruvaldehyde bis(N-methyl-thiosemicarbazone)
  • Coronary artery disease
  • Positron emission tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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