Cord Blood Hematopoietic Cell Transplantation

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Scopus citations

Abstract

Cord blood (CB) hematopoietic cell transplantation (HCT) has advanced greatly since the first transplant performed in October 1988. As of 2012, there have been over 30,000 CB transplants done for a wide variety of malignant and non-malignant disorders, most of which were performed with partially HLA-matched unrelated CB cells. Advantages of CB, compared to other stem cell sources, include readily available HLA-typed CB and a more forgiving nature in using partially HLA-mismatched cells. However, time to neutrophil, platelet, and immune cell recovery is slower. We provide a historical perspective on CB HCT, and detail the status of CB banking, clinical results, biology and immunology, and means to manipulate donor CB cells for efficacious engraftment and treatment. The status of other cells in CB that may have implications for regenerative medicine, is discussed.

Original languageEnglish (US)
Title of host publicationThomas' Hematopoietic Cell Transplantation
Subtitle of host publicationFifth Edition
PublisherWiley-Blackwell
Pages437-455
Number of pages19
Volume1-2
ISBN (Electronic)9781118416426
ISBN (Print)9781118416006
DOIs
StatePublished - Jan 1 2016

Keywords

  • Children and adults
  • Cord blood banking
  • Cord blood donor search
  • Cord blood hematopoietic stem and progenitor cells
  • Engraftment
  • Immune reconstitution
  • Malignant hematologic disorders
  • Non-malignant hematologic and genetic disorders
  • Related cord blood hematopoietic cell transplantation
  • Unrelated cord blood hematopoietic cell transplantation

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Broxmeyer, H. E., Farag, S. S., & Rocha, V. (2016). Cord Blood Hematopoietic Cell Transplantation. In Thomas' Hematopoietic Cell Transplantation: Fifth Edition (Vol. 1-2, pp. 437-455). Wiley-Blackwell. https://doi.org/10.1002/9781118416426.ch39