Cord Blood Hematopoietic Cell Transplantation

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Scopus citations


Cord blood (CB) hematopoietic cell transplantation (HCT) has advanced greatly since the first transplant performed in October 1988. As of 2012, there have been over 30,000 CB transplants done for a wide variety of malignant and non-malignant disorders, most of which were performed with partially HLA-matched unrelated CB cells. Advantages of CB, compared to other stem cell sources, include readily available HLA-typed CB and a more forgiving nature in using partially HLA-mismatched cells. However, time to neutrophil, platelet, and immune cell recovery is slower. We provide a historical perspective on CB HCT, and detail the status of CB banking, clinical results, biology and immunology, and means to manipulate donor CB cells for efficacious engraftment and treatment. The status of other cells in CB that may have implications for regenerative medicine, is discussed.

Original languageEnglish (US)
Title of host publicationThomas' Hematopoietic Cell Transplantation
Subtitle of host publicationFifth Edition
Number of pages19
ISBN (Electronic)9781118416426
ISBN (Print)9781118416006
StatePublished - Jan 1 2016


  • Children and adults
  • Cord blood banking
  • Cord blood donor search
  • Cord blood hematopoietic stem and progenitor cells
  • Engraftment
  • Immune reconstitution
  • Malignant hematologic disorders
  • Non-malignant hematologic and genetic disorders
  • Related cord blood hematopoietic cell transplantation
  • Unrelated cord blood hematopoietic cell transplantation

ASJC Scopus subject areas

  • Medicine(all)

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