Cord blood, a rich source of hematopoietic stem and progenitor cells, has been used for transplantation in both a sibling and an unrelated setting. More than 100 transplants have been done for a variety of nonmalignant diseases, including genetic immunodeficiencies and malignant disorders. The clinical results are encouraging and have demonstrated engraftment and low levels of graft-versus-host disease. Cord blood transplantation has been helped by the establishment of cord blood banks. Although there is much still to be learned regarding the biology, immunology, and transplantation of cord blood, the future of this form of transplantation is extremely promising.
ASJC Scopus subject areas
- Immunology and Allergy