Cord Blood Transplantation and the Potential for Gene Therapy: Gene Transduction Using a Recombinant Adeno‐Associated Viral Vector

HAL E. BROXMEYER, SCOTT COOPER, MARYSE ETIENNE‐JULAN, XU‐SHAN ‐S WANG, SELVARANGAN PONNAZHAGAN, STEPHEN BRAUN, LI LU, ARUN SRIVASTAVA

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Cord blood, which contains a high frequency of immature stem/progenitor cells with extensive proliferative and replating capacity in vitro was used as a clinical source of transplantable stem and progenitor cells. These cells can be efficiently transduced with new genetic material by using AAV or retroviral vectors. Using a recombinant AAV vector, high level expression of the lacZ gene under a CMV promoter was demonstrated in immature subsets of cord blood progenitor cells.

Original languageEnglish (US)
Pages (from-to)105-115
Number of pages11
JournalAnnals of the New York Academy of Sciences
Volume770
Issue number1
DOIs
StatePublished - Dec 1995

Fingerprint

Gene therapy
Fetal Blood
Genetic Therapy
Blood
Stem Cells
Genes
Transplantation
Stem cells
Lac Operon
Blood Cells
Transduction
Cord
Gene
Cells
Gene Therapy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Cord Blood Transplantation and the Potential for Gene Therapy : Gene Transduction Using a Recombinant Adeno‐Associated Viral Vector. / BROXMEYER, HAL E.; COOPER, SCOTT; ETIENNE‐JULAN, MARYSE; WANG, XU‐SHAN ‐S; PONNAZHAGAN, SELVARANGAN; BRAUN, STEPHEN; LU, LI; SRIVASTAVA, ARUN.

In: Annals of the New York Academy of Sciences, Vol. 770, No. 1, 12.1995, p. 105-115.

Research output: Contribution to journalArticle

BROXMEYER, HALE, COOPER, SCOTT, ETIENNE‐JULAN, MARYSE, WANG, XUSHANS, PONNAZHAGAN, SELVARANGAN, BRAUN, STEPHEN, LU, LI & SRIVASTAVA, ARUN 1995, 'Cord Blood Transplantation and the Potential for Gene Therapy: Gene Transduction Using a Recombinant Adeno‐Associated Viral Vector', Annals of the New York Academy of Sciences, vol. 770, no. 1, pp. 105-115. https://doi.org/10.1111/j.1749-6632.1995.tb31048.x
BROXMEYER, HAL E. ; COOPER, SCOTT ; ETIENNE‐JULAN, MARYSE ; WANG, XU‐SHAN ‐S ; PONNAZHAGAN, SELVARANGAN ; BRAUN, STEPHEN ; LU, LI ; SRIVASTAVA, ARUN. / Cord Blood Transplantation and the Potential for Gene Therapy : Gene Transduction Using a Recombinant Adeno‐Associated Viral Vector. In: Annals of the New York Academy of Sciences. 1995 ; Vol. 770, No. 1. pp. 105-115.
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