Cord Blood Transplantation and the Potential for Gene Therapy: Gene Transduction Using a Recombinant Adeno‐Associated Viral Vector

HAL E. BROXMEYER, SCOTT COOPER, MARYSE ETIENNE‐JULAN, XU‐SHAN ‐S WANG, SELVARANGAN PONNAZHAGAN, STEPHEN BRAUN, LI LU, ARUN SRIVASTAVA

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Cord blood, which contains a high frequency of immature stem/progenitor cells with extensive proliferative and replating capacity in vitro was used as a clinical source of transplantable stem and progenitor cells. These cells can be efficiently transduced with new genetic material by using AAV or retroviral vectors. Using a recombinant AAV vector, high level expression of the lacZ gene under a CMV promoter was demonstrated in immature subsets of cord blood progenitor cells.

Original languageEnglish (US)
Pages (from-to)105-115
Number of pages11
JournalAnnals of the New York Academy of Sciences
Volume770
Issue number1
DOIs
StatePublished - Dec 1995

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Fingerprint Dive into the research topics of 'Cord Blood Transplantation and the Potential for Gene Therapy: Gene Transduction Using a Recombinant Adeno‐Associated Viral Vector'. Together they form a unique fingerprint.

  • Cite this

    BROXMEYER, HAL. E., COOPER, SCOTT., ETIENNE‐JULAN, MARYSE., WANG, XUSHAN. S., PONNAZHAGAN, SELVARANGAN., BRAUN, STEPHEN., LU, LI., & SRIVASTAVA, ARUN. (1995). Cord Blood Transplantation and the Potential for Gene Therapy: Gene Transduction Using a Recombinant Adeno‐Associated Viral Vector. Annals of the New York Academy of Sciences, 770(1), 105-115. https://doi.org/10.1111/j.1749-6632.1995.tb31048.x