Abstract
This review provides a comprehensive analysis of the structure, neurochemical content, and functions of corneal nerves, with special emphasis on human corneal nerves. A revised interpretation of human corneal nerve architecture is presented based on recent observations obtained by in vivo confocal microscopy (IVCM), immunohistochemistry, and ultrastructural analyses of serial-sectioned human corneas. Current data on the neurotransmitter and neuropeptide contents of corneal nerves are discussed, as are the mechanisms by which corneal neurochemicals and associated neurotrophins modulate corneal physiology, homeostasis and wound healing. The results of recent clinical studies of topically applied neuropeptides and neurotrophins to treat neurotrophic keratitis are reviewed. Recommendations for using IVCM to evaluate corneal nerves in health and disease are presented.
| Original language | English |
|---|---|
| Pages (from-to) | 521-542 |
| Number of pages | 22 |
| Journal | Experimental Eye Research |
| Volume | 76 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2003 |
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Keywords
- Confocal microscopy
- Cornea
- Dystrophy
- Electron microscopy
- Function
- Herpes
- Immunohistochemistry
- Innervation
- LASIK
- PRK
- Review
- Wound healing
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
Cite this
Corneal nerves : Structure, contents and function. / Müller, Linda J.; Marfurt, Carl; Kruse, Friedrich; Tervo, Timo M T.
In: Experimental Eye Research, Vol. 76, No. 5, 01.05.2003, p. 521-542.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Corneal nerves
T2 - Structure, contents and function
AU - Müller, Linda J.
AU - Marfurt, Carl
AU - Kruse, Friedrich
AU - Tervo, Timo M T
PY - 2003/5/1
Y1 - 2003/5/1
N2 - This review provides a comprehensive analysis of the structure, neurochemical content, and functions of corneal nerves, with special emphasis on human corneal nerves. A revised interpretation of human corneal nerve architecture is presented based on recent observations obtained by in vivo confocal microscopy (IVCM), immunohistochemistry, and ultrastructural analyses of serial-sectioned human corneas. Current data on the neurotransmitter and neuropeptide contents of corneal nerves are discussed, as are the mechanisms by which corneal neurochemicals and associated neurotrophins modulate corneal physiology, homeostasis and wound healing. The results of recent clinical studies of topically applied neuropeptides and neurotrophins to treat neurotrophic keratitis are reviewed. Recommendations for using IVCM to evaluate corneal nerves in health and disease are presented.
AB - This review provides a comprehensive analysis of the structure, neurochemical content, and functions of corneal nerves, with special emphasis on human corneal nerves. A revised interpretation of human corneal nerve architecture is presented based on recent observations obtained by in vivo confocal microscopy (IVCM), immunohistochemistry, and ultrastructural analyses of serial-sectioned human corneas. Current data on the neurotransmitter and neuropeptide contents of corneal nerves are discussed, as are the mechanisms by which corneal neurochemicals and associated neurotrophins modulate corneal physiology, homeostasis and wound healing. The results of recent clinical studies of topically applied neuropeptides and neurotrophins to treat neurotrophic keratitis are reviewed. Recommendations for using IVCM to evaluate corneal nerves in health and disease are presented.
KW - Confocal microscopy
KW - Cornea
KW - Dystrophy
KW - Electron microscopy
KW - Function
KW - Herpes
KW - Immunohistochemistry
KW - Innervation
KW - LASIK
KW - PRK
KW - Review
KW - Wound healing
UR - http://www.scopus.com/inward/record.url?scp=0242380679&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0242380679&partnerID=8YFLogxK
U2 - 10.1016/S0014-4835(03)00050-2
DO - 10.1016/S0014-4835(03)00050-2
M3 - Article
C2 - 12697417
AN - SCOPUS:0242380679
VL - 76
SP - 521
EP - 542
JO - Experimental Eye Research
JF - Experimental Eye Research
SN - 0014-4835
IS - 5
ER -