Coronary blood flow regulation in the prediabetic metabolic syndrome

Srinath Setty, Wei Sun, Johnathan Tune

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

This study tested whether the pre-diabetic metabolic syndrome impairs coronary blood flow control sufficiently to alter the balance between coronary blood flow and myocardial metabolism. Experiments were conducted in dogs instrumented with catheters in the aorta, coronary sinus, and left ventricle and with flow transducers around the circumflex coronary artery and aorta. Coronary blood flow, myocardial oxygen consumption (MVO2), cardiac output, aortic pressure, left ventricular pressure and heart rate were measured at rest and during treadmill exercise in normal, control and high fat fed dogs. High fat feeding for ∼ six weeks increased body weight 15%, increased aortic blood pressure 10%, and induced insulin resistance. Fasting plasma insulin levels were increased 2.4-fold while plasma glucose concentration was unchanged relative to controls (5.0 ± 0.3 mM). The cardiac index increased with exercise but was not altered by high fat feeding. The metabolic syndrome reduced the slope of the relationship between coronary blood flow and MVO2 (P <0.0001) and decreased coronary venous PO2 at a given level of MVO2 (P <0.05). These findings indicate that the metabolic syndrome impairs the balance between myocardial oxygen delivery and metabolism by tonically vasoconstricting the coronary circulation.

Original languageEnglish (US)
Pages (from-to)416-423
Number of pages8
JournalBasic Research in Cardiology
Volume98
Issue number6
DOIs
StatePublished - Nov 2003
Externally publishedYes

Fingerprint

Fats
Aorta
Arterial Pressure
Dogs
Coronary Circulation
Coronary Sinus
Ventricular Pressure
Transducers
Oxygen Consumption
Cardiac Output
Heart Ventricles
Insulin Resistance
Fasting
Coronary Vessels
Catheters
Heart Rate
Body Weight
Insulin
Oxygen
Glucose

Keywords

  • Coronary blood flow
  • Dog
  • Exercise
  • Metabolic syndrome
  • Myocardial oxygen consumption

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Coronary blood flow regulation in the prediabetic metabolic syndrome. / Setty, Srinath; Sun, Wei; Tune, Johnathan.

In: Basic Research in Cardiology, Vol. 98, No. 6, 11.2003, p. 416-423.

Research output: Contribution to journalArticle

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