Correlates of acute exercise-induced ocular hypotension

Alon Harris, V. Malinovsky, B. Martin

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Purpose. To understand those factors that determine the decrease in intraocular pressure (IOP) that occurs during acute dynamic exercise. Methods. Three aspects of the exercise-IOP relationship were studied. These included graded exercise, with and without CO2 addition for isocapnia; comparison of the IOP response of trained and sedentary subjects to a fixed external work load; and exercise after ocular β-adrenoceptor blockade. Graded exercise consisted of 7 minutes each at 30 and 90 watts on a cycle ergometer, then progressive work to exhaustion. Trained and sedentary subjects were defined on the basis of the blood lactate response to fixed external work (10 minutes at 90 watts). Selective β1-adrenoceptor blockade (betaxolol) and nonselective β-adrenoceptor blockade (levobunolol) were superimposed on graded exercise. Intraocular pressure was measured using applanation tonometry. Results. Graded exercise: Intraocular pressure decreased in proportion to exercise intensity. Hypocapnia developed in the last minutes of exhausting work, but preventing hypocapnia with CO2 addition failed to lessen the decrease in IOP. Response to fixed external work load: Intraocular pressure decreased significantly more in sedentary than in trained subjects; this decline was correlated with elevations in blood lactate but not with changes in metabolic rate or plasma osmolarity. Selective and nonselective β-adrenoceptor blockade: Both drugs lowered IOP at baseline and throughout graded exercise; the drugs and exercise had apparently additive ocular hypotensive effects. Conclusions. Acute dynamic exercise lowers IOP in a graded fashion proportional to relative, not absolute, work load. The IOP decline is correlated with blood lactate but not with PCO2 or plasma osmolarity changes, and exercise potentiates the ocular hypotensive effects of β-adrenoceptor blockade.

Original languageEnglish
Pages (from-to)3852-3857
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Volume35
Issue number11
StatePublished - 1994

Fingerprint

Ocular Hypotension
Controlled Hypotension
Intraocular Pressure
Exercise
Adrenergic Receptors
Workload
Hypocapnia
Lactic Acid
Osmolar Concentration
Levobunolol
Betaxolol
Manometry
Pharmaceutical Preparations

Keywords

  • betaxolol
  • glaucoma
  • intraocular pressure
  • lactic acid
  • levobunolol

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Correlates of acute exercise-induced ocular hypotension. / Harris, Alon; Malinovsky, V.; Martin, B.

In: Investigative Ophthalmology and Visual Science, Vol. 35, No. 11, 1994, p. 3852-3857.

Research output: Contribution to journalArticle

Harris, Alon ; Malinovsky, V. ; Martin, B. / Correlates of acute exercise-induced ocular hypotension. In: Investigative Ophthalmology and Visual Science. 1994 ; Vol. 35, No. 11. pp. 3852-3857.
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