Correlates of Incident Cognitive Impairment in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study

Sarah R. Gillett, Evan L. Thacker, Abraham J. Letter, Leslie A. McClure, Virginia G. Wadley, Frederick Unverzagt, Brett M. Kissela, Richard E. Kennedy, Stephen P. Glasser, Deborah A. Levine, Mary Cushman

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: To identify approximately 500 cases of incident cognitive impairment (ICI) in a large, national sample adapting an existing cognitive test-based case definition and to examine relationships of vascular risk factors with ICI. Method: Participants were from the REGARDS study, a national sample of 30,239 African-American and White Americans. Participants included in this analysis had normal cognitive screening and no history of stroke at baseline, and at least one follow-up cognitive assessment with a three-test battery (TTB). Regression-based norms were applied to TTB scores to identify cases of ICI. Logistic regression was used to model associations with baseline vascular risk factors. Results: We identified 495 participants with ICI of 17,630 eligible participants. In multivariable modeling, income (OR 1.83 CI 1.27,2.62), stroke belt residence (OR 1.45 CI 1.18,1.78), history of transient ischemic attack (OR 1.90 CI 1.29,2.81), coronary artery disease(OR 1.32 CI 1.02,1.70), diabetes (OR 1.48 CI 1.17,1.87), obesity (OR 1.40 CI 1.05,1.86), and incident stroke (OR 2.73 CI 1.52,4.90) were associated with ICI. Conclusions: We adapted a previously validated cognitive test-based case definition to identify cases of ICI. Many previously identified risk factors were associated with ICI, supporting the criterion-related validity of our definition.

Original languageEnglish (US)
Pages (from-to)466-486
Number of pages21
JournalClinical Neuropsychologist
Volume29
Issue number4
DOIs
StatePublished - May 19 2015

Fingerprint

Stroke
Transient Ischemic Attack
Cognitive Dysfunction
Cognitive Impairment
Racial Differences
African Americans
Coronary Artery Disease
Obesity
Logistic Models
Risk Factors
vascular factor
History
Battery

Keywords

  • Cognitive disorders
  • Cognitive impairment
  • Epidemiology
  • Methods
  • Risk factors

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuropsychology and Physiological Psychology
  • Clinical Psychology
  • Arts and Humanities (miscellaneous)
  • Developmental and Educational Psychology

Cite this

Correlates of Incident Cognitive Impairment in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study. / Gillett, Sarah R.; Thacker, Evan L.; Letter, Abraham J.; McClure, Leslie A.; Wadley, Virginia G.; Unverzagt, Frederick; Kissela, Brett M.; Kennedy, Richard E.; Glasser, Stephen P.; Levine, Deborah A.; Cushman, Mary.

In: Clinical Neuropsychologist, Vol. 29, No. 4, 19.05.2015, p. 466-486.

Research output: Contribution to journalArticle

Gillett, SR, Thacker, EL, Letter, AJ, McClure, LA, Wadley, VG, Unverzagt, F, Kissela, BM, Kennedy, RE, Glasser, SP, Levine, DA & Cushman, M 2015, 'Correlates of Incident Cognitive Impairment in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study', Clinical Neuropsychologist, vol. 29, no. 4, pp. 466-486. https://doi.org/10.1080/13854046.2015.1042524
Gillett, Sarah R. ; Thacker, Evan L. ; Letter, Abraham J. ; McClure, Leslie A. ; Wadley, Virginia G. ; Unverzagt, Frederick ; Kissela, Brett M. ; Kennedy, Richard E. ; Glasser, Stephen P. ; Levine, Deborah A. ; Cushman, Mary. / Correlates of Incident Cognitive Impairment in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study. In: Clinical Neuropsychologist. 2015 ; Vol. 29, No. 4. pp. 466-486.
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