Correlation between ventromedial prefrontal cortex activation to food aromas and cue-driven eating

An fMRI study

William J A Eiler, Mario Dzemidzic, K. Rose Case, Robert Considine, David Kareken

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Food aromas are signals associated with both food's availability and pleasure. Previous research from this laboratory has shown that food aromas under fasting conditions evoke robust activation of medial prefrontal brain regions thought to reflect reward value (Bragulat et al., Obesity (Silver Spring), 18(8): 1566-1571, 2010). In the current study, 18 women (11 normal weight and 7 obese) underwent a 2-day imaging study (one after being fed and one while fasting). All were imaged on a 3T Siemens Trio-Tim scanner while sniffing two food (F; pasta and beef) odors, one non-food (NF; Douglas fir) odor, and an odorless control (CO). Prior to imaging, participants rated hunger and perceived odor qualities and completed the Dutch Eating Behavior Questionnaire (DEBQ) to assess "externality" (the extent to which eating is driven by external food cues). Across all participants, both food and non-food odors (compared to CO) elicited large blood oxygenation level dependent (BOLD) responses in olfactory and reward-related areas, including the medial prefrontal and anterior cingulate cortex, bilateral orbitofrontal cortex, and bilateral piriform cortex, amygdala, and hippocampus. However, food odors produced greater activation of medial prefrontal cortex, left lateral orbitofrontal cortex, and inferior insula than non-food odors. Moreover, there was a significant correlation between the (F > CO) BOLD response in ventromedial prefrontal cortex and "externality" sub-scale scores of the DEBQ, but only under the fed condition; no such correlation was present with the (NF > CO) response. This suggests that in those with high externality, ventromedial prefrontal cortex may inappropriately valuate external food cues in the absence of internal hunger.

Original languageEnglish
Pages (from-to)27-36
Number of pages10
JournalChemosensory Perception
Volume5
Issue number1
DOIs
StatePublished - Mar 2012

Fingerprint

Prefrontal Cortex
Cues
Eating
Magnetic Resonance Imaging
Food
Hunger
Feeding Behavior
Reward
Fasting
Pseudotsuga
Pleasure
Gyrus Cinguli
Amygdala
Silver
Odorants
Hippocampus
Obesity
Weights and Measures
Brain
Research

Keywords

  • Dutch Eating Behavior Questionnaire
  • Functional magnetic resonance imaging
  • Obesity
  • Olfaction
  • Ventromedial prefrontal cortex

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Sensory Systems

Cite this

Correlation between ventromedial prefrontal cortex activation to food aromas and cue-driven eating : An fMRI study. / Eiler, William J A; Dzemidzic, Mario; Case, K. Rose; Considine, Robert; Kareken, David.

In: Chemosensory Perception, Vol. 5, No. 1, 03.2012, p. 27-36.

Research output: Contribution to journalArticle

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