Correlation of serum concentrations of ibuprofen stereoisomers with clinical response in the treatment of hip and knee osteoarthritis

J. D. Bradley, A. C. Rudy, B. P. Katz, S. I. Ryan, L. A. Kalasinski, D. C. Brater, S. D. Hall, K. D. Brandt

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Stereoselective pharmacokinetic measurements of the active enantiomer, S-ibuprofen, were correlated with clinical response in 45 participants in a randomized double blinded 4 week comparison of ibuprofen, 1200 or 2400 mg/day, for treatment of hip or knee osteoarthritis. Ibuprofen dose correlated with S-ibuprofen area under the serum concentration curve (AUC), trough and average concentration, but not with clinical outcome. AUC of S-ibuprofen correlated with improvement in disability, rest pain and in the physician's global assessment (p = 0.02, 0.08, and 0.10, respectively), and negatively with the subject's weight and creatinine clearance (p = 0.09 and 0.07, respectively). Some individual variation in responsiveness to ibuprofen (and other nonsteroidal antiinflammatory drugs) may be attributed to pharmacokinetic differences.

Original languageEnglish (US)
Pages (from-to)130-134
Number of pages5
JournalJournal of Rheumatology
Volume19
Issue number1
StatePublished - 1992

Keywords

  • enantiomers
  • ibuprofen
  • osteoarthritis

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

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    Bradley, J. D., Rudy, A. C., Katz, B. P., Ryan, S. I., Kalasinski, L. A., Brater, D. C., Hall, S. D., & Brandt, K. D. (1992). Correlation of serum concentrations of ibuprofen stereoisomers with clinical response in the treatment of hip and knee osteoarthritis. Journal of Rheumatology, 19(1), 130-134.