Correlation of serum concentrations of ibuprofen stereoisomers with clinical response in the treatment of hip and knee osteoarthritis

J. D. Bradley, A. C. Rudy, Barry Katz, S. I. Ryan, L. A. Kalasinski, D. C. Brater, S. D. Hall, K. D. Brandt

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Stereoselective pharmacokinetic measurements of the active enantiomer, S-ibuprofen, were correlated with clinical response in 45 participants in a randomized double blinded 4 week comparison of ibuprofen, 1200 or 2400 mg/day, for treatment of hip or knee osteoarthritis. Ibuprofen dose correlated with S-ibuprofen area under the serum concentration curve (AUC), trough and average concentration, but not with clinical outcome. AUC of S-ibuprofen correlated with improvement in disability, rest pain and in the physician's global assessment (p = 0.02, 0.08, and 0.10, respectively), and negatively with the subject's weight and creatinine clearance (p = 0.09 and 0.07, respectively). Some individual variation in responsiveness to ibuprofen (and other nonsteroidal antiinflammatory drugs) may be attributed to pharmacokinetic differences.

Original languageEnglish
Pages (from-to)130-134
Number of pages5
JournalJournal of Rheumatology
Volume19
Issue number1
StatePublished - 1992

Fingerprint

Hip Osteoarthritis
Stereoisomerism
Knee Osteoarthritis
Ibuprofen
Serum
Area Under Curve
Therapeutics
Pharmacokinetics
Creatinine
Anti-Inflammatory Agents
Physicians
Weights and Measures
Pain
Pharmaceutical Preparations

Keywords

  • enantiomers
  • ibuprofen
  • osteoarthritis

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Bradley, J. D., Rudy, A. C., Katz, B., Ryan, S. I., Kalasinski, L. A., Brater, D. C., ... Brandt, K. D. (1992). Correlation of serum concentrations of ibuprofen stereoisomers with clinical response in the treatment of hip and knee osteoarthritis. Journal of Rheumatology, 19(1), 130-134.

Correlation of serum concentrations of ibuprofen stereoisomers with clinical response in the treatment of hip and knee osteoarthritis. / Bradley, J. D.; Rudy, A. C.; Katz, Barry; Ryan, S. I.; Kalasinski, L. A.; Brater, D. C.; Hall, S. D.; Brandt, K. D.

In: Journal of Rheumatology, Vol. 19, No. 1, 1992, p. 130-134.

Research output: Contribution to journalArticle

Bradley, JD, Rudy, AC, Katz, B, Ryan, SI, Kalasinski, LA, Brater, DC, Hall, SD & Brandt, KD 1992, 'Correlation of serum concentrations of ibuprofen stereoisomers with clinical response in the treatment of hip and knee osteoarthritis', Journal of Rheumatology, vol. 19, no. 1, pp. 130-134.
Bradley, J. D. ; Rudy, A. C. ; Katz, Barry ; Ryan, S. I. ; Kalasinski, L. A. ; Brater, D. C. ; Hall, S. D. ; Brandt, K. D. / Correlation of serum concentrations of ibuprofen stereoisomers with clinical response in the treatment of hip and knee osteoarthritis. In: Journal of Rheumatology. 1992 ; Vol. 19, No. 1. pp. 130-134.
@article{32ee582e6c444764ba25193fdc244cac,
title = "Correlation of serum concentrations of ibuprofen stereoisomers with clinical response in the treatment of hip and knee osteoarthritis",
abstract = "Stereoselective pharmacokinetic measurements of the active enantiomer, S-ibuprofen, were correlated with clinical response in 45 participants in a randomized double blinded 4 week comparison of ibuprofen, 1200 or 2400 mg/day, for treatment of hip or knee osteoarthritis. Ibuprofen dose correlated with S-ibuprofen area under the serum concentration curve (AUC), trough and average concentration, but not with clinical outcome. AUC of S-ibuprofen correlated with improvement in disability, rest pain and in the physician's global assessment (p = 0.02, 0.08, and 0.10, respectively), and negatively with the subject's weight and creatinine clearance (p = 0.09 and 0.07, respectively). Some individual variation in responsiveness to ibuprofen (and other nonsteroidal antiinflammatory drugs) may be attributed to pharmacokinetic differences.",
keywords = "enantiomers, ibuprofen, osteoarthritis",
author = "Bradley, {J. D.} and Rudy, {A. C.} and Barry Katz and Ryan, {S. I.} and Kalasinski, {L. A.} and Brater, {D. C.} and Hall, {S. D.} and Brandt, {K. D.}",
year = "1992",
language = "English",
volume = "19",
pages = "130--134",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "Journal of Rheumatology",
number = "1",

}

TY - JOUR

T1 - Correlation of serum concentrations of ibuprofen stereoisomers with clinical response in the treatment of hip and knee osteoarthritis

AU - Bradley, J. D.

AU - Rudy, A. C.

AU - Katz, Barry

AU - Ryan, S. I.

AU - Kalasinski, L. A.

AU - Brater, D. C.

AU - Hall, S. D.

AU - Brandt, K. D.

PY - 1992

Y1 - 1992

N2 - Stereoselective pharmacokinetic measurements of the active enantiomer, S-ibuprofen, were correlated with clinical response in 45 participants in a randomized double blinded 4 week comparison of ibuprofen, 1200 or 2400 mg/day, for treatment of hip or knee osteoarthritis. Ibuprofen dose correlated with S-ibuprofen area under the serum concentration curve (AUC), trough and average concentration, but not with clinical outcome. AUC of S-ibuprofen correlated with improvement in disability, rest pain and in the physician's global assessment (p = 0.02, 0.08, and 0.10, respectively), and negatively with the subject's weight and creatinine clearance (p = 0.09 and 0.07, respectively). Some individual variation in responsiveness to ibuprofen (and other nonsteroidal antiinflammatory drugs) may be attributed to pharmacokinetic differences.

AB - Stereoselective pharmacokinetic measurements of the active enantiomer, S-ibuprofen, were correlated with clinical response in 45 participants in a randomized double blinded 4 week comparison of ibuprofen, 1200 or 2400 mg/day, for treatment of hip or knee osteoarthritis. Ibuprofen dose correlated with S-ibuprofen area under the serum concentration curve (AUC), trough and average concentration, but not with clinical outcome. AUC of S-ibuprofen correlated with improvement in disability, rest pain and in the physician's global assessment (p = 0.02, 0.08, and 0.10, respectively), and negatively with the subject's weight and creatinine clearance (p = 0.09 and 0.07, respectively). Some individual variation in responsiveness to ibuprofen (and other nonsteroidal antiinflammatory drugs) may be attributed to pharmacokinetic differences.

KW - enantiomers

KW - ibuprofen

KW - osteoarthritis

UR - http://www.scopus.com/inward/record.url?scp=0026532681&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026532681&partnerID=8YFLogxK

M3 - Article

VL - 19

SP - 130

EP - 134

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

IS - 1

ER -