Correlations in low-frequency BOLD fluctuations reflect cortico-cortical connections

Mark J. Lowe, Mario Dzemidzic, Joseph T. Lurito, Vincent P. Mathews, Micheal D. Phillips

Research output: Contribution to journalArticle

201 Scopus citations


Cross-correlation of low-frequency temporal fluctuations (<0.08 Hz) was used to correlate widely separated anatomic regions during continuous performance of a spatial working memory task. The regions of highest correlation to right-hemisphere dorsolateral prefrontal cortex correspond to the regions of largest baseline signal change in a conventional block-style functional MRI paradigm. Additionally, it is shown that the correlations between elements of the functional network increase during performance of a task that activates the network when compared to a task that does not directly stimulate the functionally connected network. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)582-587
Number of pages6
Issue number5
StatePublished - Jan 1 2000


  • Dorsolateral prefrontal cortex
  • Functional magnetic resonance imaging
  • Physiologic noise
  • Resting state correlation
  • Working memory

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Fingerprint Dive into the research topics of 'Correlations in low-frequency BOLD fluctuations reflect cortico-cortical connections'. Together they form a unique fingerprint.

  • Cite this