Cortical representation of ipsilateral arm movements in monkey and man

Karunesh Ganguly, Lavi Secundo, Gireeja Ranade, Amy Orsborn, Edward F. Chang, Dragan F. Dimitrov, Jonathan D. Wallis, Nicholas Barbaro, Robert T. Knight, Jose M. Carmena

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

A fundamental organizational principle of the primate motor system is cortical control of contralateral limb movements. Motor areas also appear to play a role in the control of ipsilateral limb movements. Several studies in monkeys have shown that individual neurons in primary motor cortex (M1) may represent, on average, the direction of movements of the ipsilateral arm. Given the increasing body of evidence demonstrating that neural ensembles can reliably represent information with a high temporal resolution, here we characterize the distributed neural representation of ipsilateral upper limb kinematics in both monkey and man. In two macaque monkeys trained to perform center-out reaching movements, we found that the ensemble spiking activity in M1 could continuously represent ipsilateral limb position. Interestingly, this representation was more correlated with joint angles than hand position. Using bilateral electromyography recordings, we excluded the possibility that postural or mirror movements could exclusively account for these findings. In addition, linear methods could decode limb position from cortical field potentials in both monkeys. We also found that M1 spiking activity could control a biomimetic brain-machine interface reflecting ipsilateral kinematics. Finally, we recorded cortical field potentials from three human subjects and also consistently found evidence of a neural representation for ipsilateral movement parameters. Together, our results demonstrate the presence of a high-fidelity neural representation for ipsilateral movement and illustrates that it can be successfully incorporated into a brain-machine interface.

Original languageEnglish (US)
Pages (from-to)12948-12956
Number of pages9
JournalJournal of Neuroscience
Volume29
Issue number41
DOIs
StatePublished - Oct 14 2009
Externally publishedYes

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Haplorhini
Arm
Extremities
Brain-Computer Interfaces
Motor Cortex
Biomechanical Phenomena
Hand Joints
Biomimetics
Macaca
Electromyography
Upper Extremity
Primates
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Ganguly, K., Secundo, L., Ranade, G., Orsborn, A., Chang, E. F., Dimitrov, D. F., ... Carmena, J. M. (2009). Cortical representation of ipsilateral arm movements in monkey and man. Journal of Neuroscience, 29(41), 12948-12956. https://doi.org/10.1523/JNEUROSCI.2471-09.2009

Cortical representation of ipsilateral arm movements in monkey and man. / Ganguly, Karunesh; Secundo, Lavi; Ranade, Gireeja; Orsborn, Amy; Chang, Edward F.; Dimitrov, Dragan F.; Wallis, Jonathan D.; Barbaro, Nicholas; Knight, Robert T.; Carmena, Jose M.

In: Journal of Neuroscience, Vol. 29, No. 41, 14.10.2009, p. 12948-12956.

Research output: Contribution to journalArticle

Ganguly, K, Secundo, L, Ranade, G, Orsborn, A, Chang, EF, Dimitrov, DF, Wallis, JD, Barbaro, N, Knight, RT & Carmena, JM 2009, 'Cortical representation of ipsilateral arm movements in monkey and man', Journal of Neuroscience, vol. 29, no. 41, pp. 12948-12956. https://doi.org/10.1523/JNEUROSCI.2471-09.2009
Ganguly K, Secundo L, Ranade G, Orsborn A, Chang EF, Dimitrov DF et al. Cortical representation of ipsilateral arm movements in monkey and man. Journal of Neuroscience. 2009 Oct 14;29(41):12948-12956. https://doi.org/10.1523/JNEUROSCI.2471-09.2009
Ganguly, Karunesh ; Secundo, Lavi ; Ranade, Gireeja ; Orsborn, Amy ; Chang, Edward F. ; Dimitrov, Dragan F. ; Wallis, Jonathan D. ; Barbaro, Nicholas ; Knight, Robert T. ; Carmena, Jose M. / Cortical representation of ipsilateral arm movements in monkey and man. In: Journal of Neuroscience. 2009 ; Vol. 29, No. 41. pp. 12948-12956.
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