Cortical spatio-temporal dynamics underlying phonological target detection in humans

Edward F. Chang, Erik Edwards, Srikantan S. Nagarajan, Noa Fogelson, Sarang S. Dalal, Ryan T. Canolty, Heidi E. Kirsch, Nicholas Barbaro, Robert T. Knight

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Selective processing of task-relevant stimuli is critical for goaldirected behavior. We used electrocorticography to assess the spatio-temporal dynamics of cortical activation during a simple phonological target detection task, in which subjects press a button when a prespecified target syllable sound is heard. Simultaneous surface potential recordings during this task revealed a highly ordered temporal progression of high gamma (HG, 70- 200 Hz) activity across the lateral hemisphere in less than 1 sec. The sequence demonstrated concurrent regional sensory processing of speech syllables in the posterior superior temporal gyrus (STG) and speech motor cortex, and then transitioned to sequential task-dependent processing from prefrontal cortex (PFC), to the final motor response in the hand sensorimotor cortex. STG activation was modestly enhanced for target over nontarget sounds, supporting a selective gain mechanism in early sensory processing, whereas PFC was entirely selective to targets, supporting its role in guiding response behavior. These results reveal that target detection is not a single cognitive event, but rather a process of progressive target selectivity that involves large-scale rapid parallel and serial processing in sensory, cognitive, and motor structures to support goal-directed human behavior.

Original languageEnglish (US)
Pages (from-to)1437-1446
Number of pages10
JournalJournal of Cognitive Neuroscience
Volume23
Issue number6
DOIs
StatePublished - Jun 2011
Externally publishedYes

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Prefrontal Cortex
Motor Cortex
Temporal Lobe
Hand
Electrocorticography
Wernicke Area
Sensorimotor Cortex

ASJC Scopus subject areas

  • Cognitive Neuroscience

Cite this

Chang, E. F., Edwards, E., Nagarajan, S. S., Fogelson, N., Dalal, S. S., Canolty, R. T., ... Knight, R. T. (2011). Cortical spatio-temporal dynamics underlying phonological target detection in humans. Journal of Cognitive Neuroscience, 23(6), 1437-1446. https://doi.org/10.1162/jocn.2010.21466

Cortical spatio-temporal dynamics underlying phonological target detection in humans. / Chang, Edward F.; Edwards, Erik; Nagarajan, Srikantan S.; Fogelson, Noa; Dalal, Sarang S.; Canolty, Ryan T.; Kirsch, Heidi E.; Barbaro, Nicholas; Knight, Robert T.

In: Journal of Cognitive Neuroscience, Vol. 23, No. 6, 06.2011, p. 1437-1446.

Research output: Contribution to journalArticle

Chang, EF, Edwards, E, Nagarajan, SS, Fogelson, N, Dalal, SS, Canolty, RT, Kirsch, HE, Barbaro, N & Knight, RT 2011, 'Cortical spatio-temporal dynamics underlying phonological target detection in humans', Journal of Cognitive Neuroscience, vol. 23, no. 6, pp. 1437-1446. https://doi.org/10.1162/jocn.2010.21466
Chang EF, Edwards E, Nagarajan SS, Fogelson N, Dalal SS, Canolty RT et al. Cortical spatio-temporal dynamics underlying phonological target detection in humans. Journal of Cognitive Neuroscience. 2011 Jun;23(6):1437-1446. https://doi.org/10.1162/jocn.2010.21466
Chang, Edward F. ; Edwards, Erik ; Nagarajan, Srikantan S. ; Fogelson, Noa ; Dalal, Sarang S. ; Canolty, Ryan T. ; Kirsch, Heidi E. ; Barbaro, Nicholas ; Knight, Robert T. / Cortical spatio-temporal dynamics underlying phonological target detection in humans. In: Journal of Cognitive Neuroscience. 2011 ; Vol. 23, No. 6. pp. 1437-1446.
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