Cost-effectiveness of improving primary care treatment of late-life depression

Wayne J. Katon, Michael Schoenbaum, Ming Yu Fan, Christopher Callahan, John Williams, Enid Hunkeler, Linda Harpole, Xiao Hua Andrew Zhou, Christopher Langston, Jürgen Unützer

Research output: Contribution to journalArticle

169 Citations (Scopus)

Abstract

Context: Depression is a leading cause of functional impairment in elderly individuals and is associated with high medical costs, but there are large gaps in quality of treatment in primary care. Objective: To determine the incremental cost-effectiveness of the Improving Mood Promoting Access to Collaborative Treatment (IMPACT) collaborative care management program for late-life depression. Design: Randomized controlled trial with recruitment from July 1999 to August 2001. Setting: Eighteen primary care clinics from 8 health care organizations in 5 states. Participants: A total of 1801 patients 60 years or older with major depression (17%), dysthymic disorder (30%), or both (53%). Intervention: Patients were randomly assigned to the IMPACT intervention (n=906) or to usual primary care (n=895). Intervention patients were provided access to a depression care manager supervised by a psychiatrist and primary care physician. Depression care managers offered education, support of antidepressant medications prescribed in primary care, and problem-solving treatment in primary care (a brief psychotherapy). Main Outcome Measures: Total outpatient costs, depression-free days, and quality-adjusted life-years. Results: Relative to usual care, intervention patients experienced 107 (95% confidence interval [CI], 86 to 128) more depression-free days over 24 months. Total outpatient costs were $295 (95% CI, -$525 to $1115) higher during this period. The incremental outpatient cost per depression-free day was $2.76 (95% CI, -$4.95 to $10.47) and incremental outpatient costs per quality-adjusted life-year ranged from $2519 (95% CI, -$4517 to $9554) to $5037 (95% CI, -$9034 to $19 108). Results of a bootstrap analysis suggested a 25% probability that the IMPACT intervention was "dominant" (ie, lower costs and greater effectiveness). Conclusions: The IMPACT intervention is a high-value investment for older adults; it is associated with high clinical benefits at a low increment in health care costs.

Original languageEnglish (US)
Pages (from-to)1313-1320
Number of pages8
JournalArchives of General Psychiatry
Volume62
Issue number12
DOIs
StatePublished - Dec 2005
Externally publishedYes

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Cost-Benefit Analysis
Primary Health Care
Depression
Confidence Intervals
Costs and Cost Analysis
Outpatients
Quality-Adjusted Life Years
Therapeutics
Dysthymic Disorder
Brief Psychotherapy
Primary Care Physicians
Health Care Costs
Antidepressive Agents
Psychiatry
Patient Care
Randomized Controlled Trials
Outcome Assessment (Health Care)
Organizations
Delivery of Health Care
Education

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Katon, W. J., Schoenbaum, M., Fan, M. Y., Callahan, C., Williams, J., Hunkeler, E., ... Unützer, J. (2005). Cost-effectiveness of improving primary care treatment of late-life depression. Archives of General Psychiatry, 62(12), 1313-1320. https://doi.org/10.1001/archpsyc.62.12.1313

Cost-effectiveness of improving primary care treatment of late-life depression. / Katon, Wayne J.; Schoenbaum, Michael; Fan, Ming Yu; Callahan, Christopher; Williams, John; Hunkeler, Enid; Harpole, Linda; Zhou, Xiao Hua Andrew; Langston, Christopher; Unützer, Jürgen.

In: Archives of General Psychiatry, Vol. 62, No. 12, 12.2005, p. 1313-1320.

Research output: Contribution to journalArticle

Katon, WJ, Schoenbaum, M, Fan, MY, Callahan, C, Williams, J, Hunkeler, E, Harpole, L, Zhou, XHA, Langston, C & Unützer, J 2005, 'Cost-effectiveness of improving primary care treatment of late-life depression', Archives of General Psychiatry, vol. 62, no. 12, pp. 1313-1320. https://doi.org/10.1001/archpsyc.62.12.1313
Katon, Wayne J. ; Schoenbaum, Michael ; Fan, Ming Yu ; Callahan, Christopher ; Williams, John ; Hunkeler, Enid ; Harpole, Linda ; Zhou, Xiao Hua Andrew ; Langston, Christopher ; Unützer, Jürgen. / Cost-effectiveness of improving primary care treatment of late-life depression. In: Archives of General Psychiatry. 2005 ; Vol. 62, No. 12. pp. 1313-1320.
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