Coverage of large pediatric wounds with cultured epithelial autografts in congenital nevi and burns: Results and technique

Rajiv Sood, Jerone Balledux, Dimitri J. Koumanis, Haaris S. Mir, Swetanshu Chaudhari, David Roggy, Madeline Zieger, Adam Cohen, John J. Coleman

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The use of cultured epithelial autografts (CEA) for the treatment of large burn wounds has gained popularity in recent years. This technique may circumvent the restrictions of limited donor site availability and hasten permanent wound coverage for large TBSA burns. The availability of a large amount of skin from a small donor site with the promise of permanent wound coverage suggests its use in other conditions such as giant congenital nevi (GCN) as well. The risk of malignant transformation of GCN to melanoma although somewhat controversial is significant enough to warrant early excision in childhood. Cultured keratinocytes may provide one-stage coverage of these large wounds, lessening the number of surgeries and the inherent staging problems of tissue expansion or autografting. A retrospective single institution review of was done for 29 children (20 burns and 9 patients with GCN) who underwent coverage of their large surface area wounds with CEA over an 18-year period. Excellent take rates were noted; 76.4% for burn patients and 66% for patients with GCN. Several strategies in preoperative, perioperative, and postoperative care have been standardized and have helped improve outcome. The keys to success with the CEA technique have been aggressive control of wound sepsis, surgical technique, specific use of topical antimicrobials, dressings, and the standardization of nursing and physiotherapy care. Although the cost of CEA is high, the benefits to patient care make this technique an appealing choice for large wound coverage in the pediatric population.

Original languageEnglish
Pages (from-to)576-586
Number of pages11
JournalJournal of Burn Care and Research
Volume30
Issue number4
DOIs
StatePublished - Jul 2009

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Nevus
Autografts
Burns
Pediatrics
Wounds and Injuries
Tissue Donors
Nevi and Melanomas
Tissue Expansion
Preoperative Care
Perioperative Care
Postoperative Care
Autologous Transplantation
Bandages
Nursing Care
Keratinocytes
Sepsis
Patient Care
Costs and Cost Analysis
Skin
Population

ASJC Scopus subject areas

  • Emergency Medicine
  • Rehabilitation
  • Surgery

Cite this

Coverage of large pediatric wounds with cultured epithelial autografts in congenital nevi and burns : Results and technique. / Sood, Rajiv; Balledux, Jerone; Koumanis, Dimitri J.; Mir, Haaris S.; Chaudhari, Swetanshu; Roggy, David; Zieger, Madeline; Cohen, Adam; Coleman, John J.

In: Journal of Burn Care and Research, Vol. 30, No. 4, 07.2009, p. 576-586.

Research output: Contribution to journalArticle

Sood, Rajiv ; Balledux, Jerone ; Koumanis, Dimitri J. ; Mir, Haaris S. ; Chaudhari, Swetanshu ; Roggy, David ; Zieger, Madeline ; Cohen, Adam ; Coleman, John J. / Coverage of large pediatric wounds with cultured epithelial autografts in congenital nevi and burns : Results and technique. In: Journal of Burn Care and Research. 2009 ; Vol. 30, No. 4. pp. 576-586.
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