Craniofacial sequelae of lesions to facial and trigeminal motor nuclei in growing rats

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Unilateral electrolytic lesions were made in the left‐side facial motor nucleus (FMNu) of six Sprague‐Dawley rats at 35 days of age in order to correlate craniofacial sequelae with changed motoneuron function. Experimental and control rats were killed at 22, 32, 42, and 52 days postoperatively to provide muscle weight, brain histology, and dry skull preparations for analyses. Dissection, muscle weight, motoneuron count, and osteometric data revealed that lesion‐side facial and masticatory muscles were affected by the lesions. Paired t‐tests indicated that significant differences existed between weights of experimental lesion‐ and nonlesion‐side anterior digastric, temporalis, masseteric complex, and medial pterygoid muscles, numbers of facial and trigeminal motoneurons, and several skeletal dimensions of the skull. Basicranial dimensions of experimental animals were least affected by the lesion, whereas zygomatic arch, dorsal facial region, and mandibular condyle dimensions were most affected. Statistical analyses also detected significant differences between experimental and control groups for several skeletal dimensions of the skull. Data indicated that damage to the trigeminal motor nucleus (TMNu) was secondary to the primary lesion in the FMNu. Motoneurons within the facial and trigeminal neuromuscular complexes (FNC and TNC) play an important role in craniofacial growth and development.

Original languageEnglish (US)
Pages (from-to)87-103
Number of pages17
JournalAmerican Journal of Physical Anthropology
Volume76
Issue number1
DOIs
StatePublished - May 1988
Externally publishedYes

Keywords

  • Craniofacial
  • Form
  • Growth
  • Motoneuron
  • Neuromuscular

ASJC Scopus subject areas

  • Anatomy
  • Anthropology

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