Creating and evaluating genetic tests predictive of drug response

Scott T. Weiss, Howard L. McLeod, David A. Flockhart, M. Eileen Dolan, Neal L. Benowitz, Julie A. Johnson, Mark J. Ratain, Kathleen M. Giacomini

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

A key goal of pharmacogenetics - the use of genetic variation to elucidate inter-individual variation in drug treatment response - is to aid the development of predictive genetic tests that could maximize drug efficacy and minimize drug toxicity. The completion of the Human Genome Project and the associated HapMap Project, together with advances in technologies for investigating genetic variation, have greatly advanced the potential to develop such tests; however, many challenges remain. With the aim of helping to address some of these challenges, this article discusses the steps that are involved in the development of predictive tests for drug treatment response based on genetic variation, and factors that influence the development and performance of these tests.

Original languageEnglish (US)
Pages (from-to)568-574
Number of pages7
JournalNature Reviews Drug Discovery
Volume7
Issue number7
DOIs
StatePublished - Jul 1 2008

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Pharmaceutical Preparations
HapMap Project
Human Genome Project
Pharmacogenetics
Drug-Related Side Effects and Adverse Reactions
Technology

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Weiss, S. T., McLeod, H. L., Flockhart, D. A., Dolan, M. E., Benowitz, N. L., Johnson, J. A., ... Giacomini, K. M. (2008). Creating and evaluating genetic tests predictive of drug response. Nature Reviews Drug Discovery, 7(7), 568-574. https://doi.org/10.1038/nrd2520

Creating and evaluating genetic tests predictive of drug response. / Weiss, Scott T.; McLeod, Howard L.; Flockhart, David A.; Dolan, M. Eileen; Benowitz, Neal L.; Johnson, Julie A.; Ratain, Mark J.; Giacomini, Kathleen M.

In: Nature Reviews Drug Discovery, Vol. 7, No. 7, 01.07.2008, p. 568-574.

Research output: Contribution to journalArticle

Weiss, ST, McLeod, HL, Flockhart, DA, Dolan, ME, Benowitz, NL, Johnson, JA, Ratain, MJ & Giacomini, KM 2008, 'Creating and evaluating genetic tests predictive of drug response', Nature Reviews Drug Discovery, vol. 7, no. 7, pp. 568-574. https://doi.org/10.1038/nrd2520
Weiss ST, McLeod HL, Flockhart DA, Dolan ME, Benowitz NL, Johnson JA et al. Creating and evaluating genetic tests predictive of drug response. Nature Reviews Drug Discovery. 2008 Jul 1;7(7):568-574. https://doi.org/10.1038/nrd2520
Weiss, Scott T. ; McLeod, Howard L. ; Flockhart, David A. ; Dolan, M. Eileen ; Benowitz, Neal L. ; Johnson, Julie A. ; Ratain, Mark J. ; Giacomini, Kathleen M. / Creating and evaluating genetic tests predictive of drug response. In: Nature Reviews Drug Discovery. 2008 ; Vol. 7, No. 7. pp. 568-574.
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