Critical period for foveal fine structure in children with regressed retinopathy of prematurity

Jingyun Wang, Rand Spencer, Joel N. Leffler, Eileen E. Birch

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

PURPOSE: Midgestation is a critical period in the formation of the foveal avascular zone. The authors evaluated the effects of preterm birth on foveal structure in children with regressed retinopathy of prematurity. METHODS: Children with regressed retinopathy of prematurity with normal-appearing posterior poles (n = 26) and full-term control children (n = 56) were investigated. Frequency-domain optical coherence tomography 9-mm line scans across the fovea were obtained from right eyes. Using a customized segmentation program in MATLAB, total retinal thickness and the thickness of individual retinal layer regions were measured at the fovea (0°) and throughout ±8°. RESULTS: Total thickness of the fovea in the retinopathy of prematurity group (287.7 ± 47.6 μm) was greater than that in the control group (230.1 ± 18.2 μm). Bilinear fitting was performed to examine the relationship between total thickness and gestational age. Before 28 weeks, foveal thickness decreased with gestational age (14.3 μm/week); after 28 weeks, foveal thickness decreased only slightly (2.73 μm/week). Inner retinal layers contributed to the difference in thickness between groups more than outer layers. Foveal thickness was correlated with gestational age at birth but not with visual acuity or refractive error. CONCLUSION: Preterm birth before 28 weeks of gestational age was associated with a failure of the inner retinal layers to migrate away from the fovea, resulting in increased foveal thickness.

Original languageEnglish
Pages (from-to)330-339
Number of pages10
JournalRetina
Volume32
Issue number2
DOIs
StatePublished - Feb 2012

Fingerprint

Retinopathy of Prematurity
Gestational Age
Premature Birth
Refractive Errors
Optical Coherence Tomography
Visual Acuity
Parturition
Control Groups
Critical Period (Psychology)

Keywords

  • children
  • fovea
  • OCT
  • retina
  • retinopathy of prematurity

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Critical period for foveal fine structure in children with regressed retinopathy of prematurity. / Wang, Jingyun; Spencer, Rand; Leffler, Joel N.; Birch, Eileen E.

In: Retina, Vol. 32, No. 2, 02.2012, p. 330-339.

Research output: Contribution to journalArticle

Wang, Jingyun ; Spencer, Rand ; Leffler, Joel N. ; Birch, Eileen E. / Critical period for foveal fine structure in children with regressed retinopathy of prematurity. In: Retina. 2012 ; Vol. 32, No. 2. pp. 330-339.
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