Critical review of the Appropriate Use Criteria for amyloid imaging: Effect on diagnosis and patient care

Liana G. Apostolova, Janelle M. Haider, Naira Goukasian, Gil D. Rabinovici, Gael Chételat, John M. Ringman, Sarah Kremen, Joshua D. Grill, Lucas Restrepo, Mario F. Mendez, Daniel H. Silverman

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Introduction The utility of the Appropriate Use Criteria (AUC) for amyloid imaging is not established. Methods Fifty-three cognitively impaired patients with clinical F18-florbetapir imaging were classified as early and late onset, as well as AUC-consistent or AUC-inconsistent. Chi-square statistics and t test were used to compare demographic characteristics and clinical outcomes as appropriate. Results Early-onset patients were more likely to be amyloid positive. Change in diagnosis was more frequent in late-onset cases. Change in therapy was more common in early-onset cases. AUC-consistent and AUC-inconsistent cases had comparable rates of amyloid positivity. We saw no difference in the rate of treatment changes in the AUC-consistent group as opposed to the AUC-inconsistent group. Discussion The primary role of amyloid imaging in the early-onset group was to confirm the clinically suspected etiology, and in the late-onset group in detecting amyloid-negative cases. The rate of therapeutic changes was significantly greater in the early-onset cases.

Original languageEnglish (US)
Pages (from-to)15-22
Number of pages8
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume5
DOIs
StatePublished - 2016

Keywords

  • Alzheimer's disease (AD)
  • Amyloid
  • Appropriate use criteria (AUC)
  • Mild cognitive impairment (MCI)
  • Positron emission tomography (PET)

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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    Apostolova, L. G., Haider, J. M., Goukasian, N., Rabinovici, G. D., Chételat, G., Ringman, J. M., Kremen, S., Grill, J. D., Restrepo, L., Mendez, M. F., & Silverman, D. H. (2016). Critical review of the Appropriate Use Criteria for amyloid imaging: Effect on diagnosis and patient care. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 5, 15-22. https://doi.org/10.1016/j.dadm.2016.12.001