Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis

Huiling Cao, Ke Zhu, Lugui Qiu, Shuai Li, Hanjie Niu, Mu Hao, Shengyong Yang, Zhongfang Zhao, Yumei Lai, Judith L. Anderson, Jie Fan, Hee Jeong Im, Di Chen, G. David Roodman, Guozhi Xiao

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: Myeloma cells cause abnormal osteoclast formation and osteolysis. Results: Myeloma cells up-regulate AKT in osteoclast precursors and promote osteoclast formation. Systemic AKT inhibition blocks the myeloma-induced osteolysis and tumor growth in bone. Conclusion: AKT is critical for the myeloma promotion of osteoclast formation and osteolysis. Significance: AKT could be a useful target for treating patients with myeloma bone disease.

Original languageEnglish
Pages (from-to)30399-30410
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number42
DOIs
StatePublished - Oct 18 2013

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Myeloma Proteins
Osteolysis
Osteoclasts
Bone
Proteins
Bone Diseases
Bone Development
Tumors
Up-Regulation
Neoplasms

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis. / Cao, Huiling; Zhu, Ke; Qiu, Lugui; Li, Shuai; Niu, Hanjie; Hao, Mu; Yang, Shengyong; Zhao, Zhongfang; Lai, Yumei; Anderson, Judith L.; Fan, Jie; Im, Hee Jeong; Chen, Di; Roodman, G. David; Xiao, Guozhi.

In: Journal of Biological Chemistry, Vol. 288, No. 42, 18.10.2013, p. 30399-30410.

Research output: Contribution to journalArticle

Cao, H, Zhu, K, Qiu, L, Li, S, Niu, H, Hao, M, Yang, S, Zhao, Z, Lai, Y, Anderson, JL, Fan, J, Im, HJ, Chen, D, Roodman, GD & Xiao, G 2013, 'Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis', Journal of Biological Chemistry, vol. 288, no. 42, pp. 30399-30410. https://doi.org/10.1074/jbc.M113.469973
Cao, Huiling ; Zhu, Ke ; Qiu, Lugui ; Li, Shuai ; Niu, Hanjie ; Hao, Mu ; Yang, Shengyong ; Zhao, Zhongfang ; Lai, Yumei ; Anderson, Judith L. ; Fan, Jie ; Im, Hee Jeong ; Chen, Di ; Roodman, G. David ; Xiao, Guozhi. / Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 42. pp. 30399-30410.
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AU - Hao, Mu

AU - Yang, Shengyong

AU - Zhao, Zhongfang

AU - Lai, Yumei

AU - Anderson, Judith L.

AU - Fan, Jie

AU - Im, Hee Jeong

AU - Chen, Di

AU - Roodman, G. David

AU - Xiao, Guozhi

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N2 - Background: Myeloma cells cause abnormal osteoclast formation and osteolysis. Results: Myeloma cells up-regulate AKT in osteoclast precursors and promote osteoclast formation. Systemic AKT inhibition blocks the myeloma-induced osteolysis and tumor growth in bone. Conclusion: AKT is critical for the myeloma promotion of osteoclast formation and osteolysis. Significance: AKT could be a useful target for treating patients with myeloma bone disease.

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