Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis

Huiling Cao, Ke Zhu, Lugui Qiu, Shuai Li, Hanjie Niu, Mu Hao, Shengyong Yang, Zhongfang Zhao, Yumei Lai, Judith L. Anderson, Jie Fan, Hee Jeong Im, Di Chen, G. David Roodman, Guozhi Xiao

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36 Scopus citations

Abstract

Background: Myeloma cells cause abnormal osteoclast formation and osteolysis. Results: Myeloma cells up-regulate AKT in osteoclast precursors and promote osteoclast formation. Systemic AKT inhibition blocks the myeloma-induced osteolysis and tumor growth in bone. Conclusion: AKT is critical for the myeloma promotion of osteoclast formation and osteolysis. Significance: AKT could be a useful target for treating patients with myeloma bone disease.

Original languageEnglish (US)
Pages (from-to)30399-30410
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number42
DOIs
StatePublished - Oct 18 2013

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Cao, H., Zhu, K., Qiu, L., Li, S., Niu, H., Hao, M., Yang, S., Zhao, Z., Lai, Y., Anderson, J. L., Fan, J., Im, H. J., Chen, D., Roodman, G. D., & Xiao, G. (2013). Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis. Journal of Biological Chemistry, 288(42), 30399-30410. https://doi.org/10.1074/jbc.M113.469973