Critical role of NF-κB in pancreatic cancer

Lakshmi Prabhu, Rasika Mundade, Murray Korc, Patrick J. Loehrer, Tao Lu

Research output: Contribution to journalReview article

68 Scopus citations

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, and in spite of intense efforts there are limited therapeutic options for patients with PDAC. PDACs harbor a high frequency of Kras mutations and other driver mutations that lead to altered signaling pathways and contribute to therapeutic resistance. Importantly, constitutive activation of nuclear factor κB (NF-κB) is frequently observed in PDAC. An increasing body of evidence suggests that both classical and non-classical NF-κB pathways play a crucial role in PDAC development and progression. In this review, we update the most recent advances regarding different aspects of NF-κB involvement in PDAC development and progression, emphasizing its potential as a therapeutic target and the need to discover pathway-specific cytosolic NF-κB regulators which could be used to design novel therapeutic strategies for PDAC.

Original languageEnglish (US)
Pages (from-to)10969-10975
Number of pages7
JournalOncotarget
Volume5
Issue number22
DOIs
StatePublished - Jan 1 2014

Keywords

  • NF-κB
  • Pancreatic cancer

ASJC Scopus subject areas

  • Oncology

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