Cross calibration in longitudinal studies

Walter T. Ambrosius, Siu Hui

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In a long-running longitudinal study using complex machinery to obtain measurements, it is sometimes necessary to replace the machine. This can result in lack of continuity in the measurements that can overwhelm any treatment effect or time trend. We propose a Bayesian procedure implemented using Markov chain Monte Carlo to calibrate the measurements on the old machine utilizing both person-specific and population information. The goal is to convert the previous measurements to values that can be treated as though they were made on the new machine. This methodology is applied to a bone mineral density study where the first densitometer uses gadolinium as the energy source (Lunar DP-3) and the second uses X-rays (Hologic QDR-1000W). Finally, simulation results are presented to show the superiority of the proposed method over existing methods of cross calibration.

Original languageEnglish
Pages (from-to)2845-2861
Number of pages17
JournalStatistics in Medicine
Volume23
Issue number18
DOIs
StatePublished - Sep 30 2004

Fingerprint

Longitudinal Study
Calibration
Longitudinal Studies
Markov Chains
Gadolinium
Bone Density
Treatment Effects
Markov Chain Monte Carlo
Bone
X-Rays
Convert
Person
Population
Necessary
Methodology
Energy
Simulation

Keywords

  • Bayes
  • BUGS
  • Cross calibration
  • Longitudinal data
  • Markov chain Monte Carlo (MCMC)

ASJC Scopus subject areas

  • Epidemiology

Cite this

Cross calibration in longitudinal studies. / Ambrosius, Walter T.; Hui, Siu.

In: Statistics in Medicine, Vol. 23, No. 18, 30.09.2004, p. 2845-2861.

Research output: Contribution to journalArticle

Ambrosius, Walter T. ; Hui, Siu. / Cross calibration in longitudinal studies. In: Statistics in Medicine. 2004 ; Vol. 23, No. 18. pp. 2845-2861.
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