Crossmatch-positive liver transplantation in patients receiving thymoglobulin-rituximab induction

Chandrashekhar A. Kubal, Richard S. Mangus, Romil Saxena, Andrew Lobashevsky, Nancy Higgins, Avinash Agarwal, Jonathan A. Fridell, A. Joseph Tector

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Background: Positive crossmatch (CM) in liver transplantation (LT) is associated with worse outcomes. Role of induction immunosuppression in this setting remains to be studied. Methods: One thousand consecutive LT patients receiving rabbit antithymocyte globulin±rituximab induction were studied. Pretransplantation sera of 55 CM-positive (CM+) patients were tested for C1q-fixing donor-specific antibodies (DSA). Diagnosis of antibody-mediated rejection required presence of diffuse vascular C4d expression on liver biopsies. Results: CM was positive in 112 (11%) recipients. Antibody-mediated rejection was observed in 3 (0.03%) patients, whereas acute cellular rejection (ACR) occurred in 31 (3%) patients. CM+ status was associated with a higher incidence of ACR (9% in CM+ vs. 2% in CM-negative [CM -]; P<0.01) and chronic rejection (4% in CM+ vs. 1% in CM-; P<0.01). Graft survival was slightly lower in CM+ patients (at 1 year; 85% in CM+ vs. 89% in CM-; P=0.26). Patients with autoimmune hepatitis, primary sclerosing cholangitis, and primary biliary cirrhosis as a group had a tendency toward CM+ status as well as developing ACR. Upon multivariate analysis, CM status was the strongest predictor of ACR (B=1.14; P=0.02). Only half of CM+ patients harbored C1q-fixing DSA. Presence of C1q-fixing DSA was not associated with increased incidence of ACR. Conclusions: In LT, CM+ status is associated with an increased incidence of acute rejection, chronic rejection, and slightly worse graft survival. With the use of rabbit antithymocyte globulin±rituximab induction, overall low rejection rates can be achieved in CM+ LT.

Original languageEnglish (US)
Pages (from-to)56-63
Number of pages8
JournalTransplantation
Volume97
Issue number1
DOIs
StatePublished - Jan 15 2014

Keywords

  • Acute rejection
  • Alloantibody
  • Chronic rejection
  • Crossmatch
  • Graft loss
  • Liver transplant
  • Sensitized recipient

ASJC Scopus subject areas

  • Transplantation

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