Crystal-associated nephropathy in patients with brushite nephrolithiasis

Andrew P. Evan, James E. Lingeman, Fredric L. Coe, Youzhi Shao, Joan H. Parks, Sharon B. Bledsoe, Carrie L. Phillips, Stephen Bonsib, Elaine M. Worcester, Andre J. Sommer, Sam C. Kim, William W. Tinmouth, Marc Grynpas

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

Background. We have biopsied the renal cortex and papillae of patients who form brushite renal stones asking if this unusual stone type is associated with specific tissue changes. We contrasted these with biopsies of 15 calcium oxalate stone formers, three stone formers with intestinal bypass, and four normal subjects. Methods. We studied all ten brushite stone formers treated with percutaneous nephrolithotomy (PNL) during the past 3 years using digital video imaging of renal papillae, and obtained cortical and papillary biopsies. Biopsies were analyzed by light and electron microscopy, microinfrared spectroscopy, and electron diffraction. Results. Apatite crystals plugged scattered terminal collecting ducts whose cells were injured or dead, and surrounding interstitium inflamed and fibrotic. White papillary deposits of interstitial apatite particles, so called Randall's plaque, were also present. Glomerular changes and cortical tubular atrophy and interstitial fibrosis were moderate to severe. Conclusion. Brushite stone formers combine the interstitial plaque of calcium oxalate stone formers with the collecting duct apatite plugs found in stone formers with intestinal bypass. Collecting duct injury and interstitial fibrosis are severe. Prominent cortical fibrosis, tubule atrophy, and glomerular pathology seem secondary to the collecting duct plugging. We believe crystallization obstructs and destroys terminal collecting duct segments thereby damaging nephrons, perhaps via intranephronal obstruction, and producing a hitherto unrecognized renal disease.

Original languageEnglish
Pages (from-to)576-591
Number of pages16
JournalKidney International
Volume67
Issue number2
DOIs
StatePublished - Feb 2005

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Nephrolithiasis
Apatites
Jejunoileal Bypass
Kidney
Calcium Oxalate
Fibrosis
Biopsy
Atrophy
Percutaneous Nephrostomy
Nephrons
Crystallization
Spectrum Analysis
Electron Microscopy
Electrons
Pathology
Light
dibasic calcium phosphate dihydrate
Wounds and Injuries

Keywords

  • Calcium phosphate
  • Extracorporeal shockwave lithotripsy
  • Kidney calculi

ASJC Scopus subject areas

  • Nephrology

Cite this

Evan, A. P., Lingeman, J. E., Coe, F. L., Shao, Y., Parks, J. H., Bledsoe, S. B., ... Grynpas, M. (2005). Crystal-associated nephropathy in patients with brushite nephrolithiasis. Kidney International, 67(2), 576-591. https://doi.org/10.1111/j.1523-1755.2005.67114.x

Crystal-associated nephropathy in patients with brushite nephrolithiasis. / Evan, Andrew P.; Lingeman, James E.; Coe, Fredric L.; Shao, Youzhi; Parks, Joan H.; Bledsoe, Sharon B.; Phillips, Carrie L.; Bonsib, Stephen; Worcester, Elaine M.; Sommer, Andre J.; Kim, Sam C.; Tinmouth, William W.; Grynpas, Marc.

In: Kidney International, Vol. 67, No. 2, 02.2005, p. 576-591.

Research output: Contribution to journalArticle

Evan, AP, Lingeman, JE, Coe, FL, Shao, Y, Parks, JH, Bledsoe, SB, Phillips, CL, Bonsib, S, Worcester, EM, Sommer, AJ, Kim, SC, Tinmouth, WW & Grynpas, M 2005, 'Crystal-associated nephropathy in patients with brushite nephrolithiasis', Kidney International, vol. 67, no. 2, pp. 576-591. https://doi.org/10.1111/j.1523-1755.2005.67114.x
Evan, Andrew P. ; Lingeman, James E. ; Coe, Fredric L. ; Shao, Youzhi ; Parks, Joan H. ; Bledsoe, Sharon B. ; Phillips, Carrie L. ; Bonsib, Stephen ; Worcester, Elaine M. ; Sommer, Andre J. ; Kim, Sam C. ; Tinmouth, William W. ; Grynpas, Marc. / Crystal-associated nephropathy in patients with brushite nephrolithiasis. In: Kidney International. 2005 ; Vol. 67, No. 2. pp. 576-591.
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