Crystal structure of the tyrosine kinase domain of the human insulin receptor

Stevan R. Hubbard, Lei Wei, Wayne A. Hendrickson

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Abstract

The X-ray crystal structure of the tyrosine kinase domain of the human insulin receptor has been determined by multiwavelength anomalous diffraction phasing and refined to 2.1 Å resolution. The structure reveals the determinants of substrate preference for tyrosine rather than serine or threonine and a novel autoinhibition mechanism whereby one of the tyrosines that is autophosphorylated in response to insulin, Tyr 1,162, is bound in the active site.

Original languageEnglish (US)
Pages (from-to)746-754
Number of pages9
JournalNature
Volume372
Issue number6508
DOIs
StatePublished - Jan 1 1994

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