CSF neuropeptides in euthymic bipolar patients and controls

W. H. Berrettini, J. I. Nurnberger, R. L. Zerbe, P. W. Gold, G. P. Chrousos, T. Tomai

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Abstract

Levels of vasopressin, somatostatin, neurotensin, vasoactive intestinal peptide, corticotrophin-releasing factor and adrenocorticotrophin in CSF were determined in lithium-treated and unmedicated euthymic bipolar patients and controls, in a search for a trait marker in affective disorder. No group differences in levels of these peptides were found. Highly significant positive correlations were found among these peptides (with the exception of neurotensin), suggesting that their presence of CSF is functionally significant, as opposed to the result of random diffusion from the interstitial space of the brain.

Original languageEnglish (US)
Pages (from-to)208-212
Number of pages5
JournalBritish Journal of Psychiatry
Volume150
Issue numberFEB.
StatePublished - Apr 3 1987
Externally publishedYes

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ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Berrettini, W. H., Nurnberger, J. I., Zerbe, R. L., Gold, P. W., Chrousos, G. P., & Tomai, T. (1987). CSF neuropeptides in euthymic bipolar patients and controls. British Journal of Psychiatry, 150(FEB.), 208-212.