CSF Perfusion to Treat Intraventricular Penicillin Toxicity

John T. Callaghan, James I. Ausman, Robert Clubb

Research output: Contribution to journalArticle

5 Scopus citations


A shunt infection and meningitis developed in a patient receiving methotrexate intravenously for CNS leukemia. Convulsions and respiratory failure followed the intraventricular administration of 300,000 units of penicillin G potassium. Perfusion with 900 mL of Ringer's lactate removed an amount of penicillin equal to that injected intraventricularly plus some from systemic treatment.

Original languageEnglish (US)
Pages (from-to)390-391
Number of pages2
JournalArchives of Neurology
Issue number6
StatePublished - Jun 1981

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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