CSF Perfusion to Treat Intraventricular Penicillin Toxicity

John T. Callaghan; James I. Ausman; Robert Clubb

doi:10.1001/archneur.1981.00510060092022

CSF Perfusion to Treat Intraventricular Penicillin Toxicity

John T. Callaghan, James I. Ausman, Robert Clubb

Clinical Pharmacology

Research output: Contribution to journal › Article

5 Scopus citations

Abstract

A shunt infection and meningitis developed in a patient receiving methotrexate intravenously for CNS leukemia. Convulsions and respiratory failure followed the intraventricular administration of 300,000 units of penicillin G potassium. Perfusion with 900 mL of Ringer's lactate removed an amount of penicillin equal to that injected intraventricularly plus some from systemic treatment.

Original language	English (US)
Pages (from-to)	390-391
Number of pages	2
Journal	Archives of Neurology
Volume	38
Issue number	6
DOIs	https://doi.org/10.1001/archneur.1981.00510060092022
State	Published - Jun 1981

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Clinical Neurology

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Callaghan, J. T., Ausman, J. I., & Clubb, R. (1981). CSF Perfusion to Treat Intraventricular Penicillin Toxicity. Archives of Neurology, 38(6), 390-391. https://doi.org/10.1001/archneur.1981.00510060092022

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abstract = "A shunt infection and meningitis developed in a patient receiving methotrexate intravenously for CNS leukemia. Convulsions and respiratory failure followed the intraventricular administration of 300,000 units of penicillin G potassium. Perfusion with 900 mL of Ringer's lactate removed an amount of penicillin equal to that injected intraventricularly plus some from systemic treatment.",

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