CT and image processing non-invasive indicators of sickle cell secondary pulmonary hypertension

Marius George Linguraru, Babak J. Orandi, Robert L. Van Uitert, Nisha Mukherjee, Ronald M. Summers, Mark T. Gladwin, Roberto Machado, Bradford J. Wood

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

This retrospective study investigates the potential of image analysis to quantify for the presence and extent of pulmonary hypertension secondary to sickle cell disease (SCD). A combination of fast marching and geodesic active contours level sets were employed to segment the pulmonary artery from smoothed CT-Angiography images from 16 SCD patients and 16 matching controls. An algorithm based on fast marching methods was used to compute the centerline of the segmented arteries to measure automatically the diameters of the pulmonary trunk and first branches of the pulmonary arteries. Results show that the pulmonary trunk and arterial branches are significantly larger in diameter in SCD patients as compared to controls (p-values of 0.002 for trunk and 0.0003 for branches). For validation, the results were compared with manually measured values and did not demonstrate significant difference (mean p-values 0.71). CT with image processing shows great potential as a surrogate indicator of pulmonary hemodynamics or response to therapy, which could be an important tool for drug discovery and noninvasive clinical surveillance.

Original languageEnglish (US)
Title of host publicationProceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
Pages859-862
Number of pages4
StatePublished - Dec 1 2008
Externally publishedYes
Event30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - Vancouver, BC, Canada
Duration: Aug 20 2008Aug 25 2008

Other

Other30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
CountryCanada
CityVancouver, BC
Period8/20/088/25/08

Fingerprint

Sickle Cell Anemia
Pulmonary Hypertension
Image processing
Lung
Pulmonary Artery
Angiography
Hemodynamics
Drug Discovery
Image analysis
Retrospective Studies
Arteries
Therapeutics

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Linguraru, M. G., Orandi, B. J., Van Uitert, R. L., Mukherjee, N., Summers, R. M., Gladwin, M. T., ... Wood, B. J. (2008). CT and image processing non-invasive indicators of sickle cell secondary pulmonary hypertension. In Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 (pp. 859-862). [4649289]

CT and image processing non-invasive indicators of sickle cell secondary pulmonary hypertension. / Linguraru, Marius George; Orandi, Babak J.; Van Uitert, Robert L.; Mukherjee, Nisha; Summers, Ronald M.; Gladwin, Mark T.; Machado, Roberto; Wood, Bradford J.

Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08. 2008. p. 859-862 4649289.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Linguraru, MG, Orandi, BJ, Van Uitert, RL, Mukherjee, N, Summers, RM, Gladwin, MT, Machado, R & Wood, BJ 2008, CT and image processing non-invasive indicators of sickle cell secondary pulmonary hypertension. in Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08., 4649289, pp. 859-862, 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08, Vancouver, BC, Canada, 8/20/08.
Linguraru MG, Orandi BJ, Van Uitert RL, Mukherjee N, Summers RM, Gladwin MT et al. CT and image processing non-invasive indicators of sickle cell secondary pulmonary hypertension. In Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08. 2008. p. 859-862. 4649289
Linguraru, Marius George ; Orandi, Babak J. ; Van Uitert, Robert L. ; Mukherjee, Nisha ; Summers, Ronald M. ; Gladwin, Mark T. ; Machado, Roberto ; Wood, Bradford J. / CT and image processing non-invasive indicators of sickle cell secondary pulmonary hypertension. Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08. 2008. pp. 859-862
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