CT and image processing non-invasive indicators of sickle cell secondary pulmonary hypertension.

Marius George Linguraru, Babak J. Orandi, Robert L. Van Uitert, Nisha Mukherjee, Ronald M. Summers, Mark T. Gladwin, Roberto F. Machado, Bradford J. Wood

Research output: Contribution to journalArticle

Abstract

This retrospective study investigates the potential of image analysis to quantify for the presence and extent of pulmonary hypertension secondary to sickle cell disease (SCD). A combination of fast marching and geodesic active contours level sets were employed to segment the pulmonary artery from smoothed CT-Angiography images from 16 SCD patients and 16 matching controls. An algorithm based on fast marching methods was used to compute the centerline of the segmented arteries to measure automatically the diameters of the pulmonary trunk and first branches of the pulmonary arteries. Results show that the pulmonary trunk and arterial branches are significantly larger in diameter in SCD patients as compared to controls (p-values of 0.002 for trunk and 0.0003 for branches). For validation, the results were compared with manually measured values and did not demonstrate significant difference (mean p-values 0.71). CT with image processing shows great potential as a surrogate indicator of pulmonary hemodynamics or response to therapy, which could be an important tool for drug discovery and noninvasive clinical surveillance.

Original languageEnglish (US)
Pages (from-to)859-862
Number of pages4
JournalConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
StatePublished - Dec 1 2008
Externally publishedYes

Fingerprint

Sickle Cell Anemia
Pulmonary Hypertension
Image processing
Lung
Pulmonary Artery
Angiography
Hemodynamics
Drug Discovery
Image analysis
Retrospective Studies
Arteries
Therapeutics

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

CT and image processing non-invasive indicators of sickle cell secondary pulmonary hypertension. / Linguraru, Marius George; Orandi, Babak J.; Van Uitert, Robert L.; Mukherjee, Nisha; Summers, Ronald M.; Gladwin, Mark T.; Machado, Roberto F.; Wood, Bradford J.

In: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 01.12.2008, p. 859-862.

Research output: Contribution to journalArticle

@article{14e6e342494d447088f64fa8bca8228c,
title = "CT and image processing non-invasive indicators of sickle cell secondary pulmonary hypertension.",
abstract = "This retrospective study investigates the potential of image analysis to quantify for the presence and extent of pulmonary hypertension secondary to sickle cell disease (SCD). A combination of fast marching and geodesic active contours level sets were employed to segment the pulmonary artery from smoothed CT-Angiography images from 16 SCD patients and 16 matching controls. An algorithm based on fast marching methods was used to compute the centerline of the segmented arteries to measure automatically the diameters of the pulmonary trunk and first branches of the pulmonary arteries. Results show that the pulmonary trunk and arterial branches are significantly larger in diameter in SCD patients as compared to controls (p-values of 0.002 for trunk and 0.0003 for branches). For validation, the results were compared with manually measured values and did not demonstrate significant difference (mean p-values 0.71). CT with image processing shows great potential as a surrogate indicator of pulmonary hemodynamics or response to therapy, which could be an important tool for drug discovery and noninvasive clinical surveillance.",
author = "Linguraru, {Marius George} and Orandi, {Babak J.} and {Van Uitert}, {Robert L.} and Nisha Mukherjee and Summers, {Ronald M.} and Gladwin, {Mark T.} and Machado, {Roberto F.} and Wood, {Bradford J.}",
year = "2008",
month = "12",
day = "1",
language = "English (US)",
pages = "859--862",
journal = "Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference",
issn = "1557-170X",
publisher = "Institute of Electrical and Electronics Engineers Inc.",

}

TY - JOUR

T1 - CT and image processing non-invasive indicators of sickle cell secondary pulmonary hypertension.

AU - Linguraru, Marius George

AU - Orandi, Babak J.

AU - Van Uitert, Robert L.

AU - Mukherjee, Nisha

AU - Summers, Ronald M.

AU - Gladwin, Mark T.

AU - Machado, Roberto F.

AU - Wood, Bradford J.

PY - 2008/12/1

Y1 - 2008/12/1

N2 - This retrospective study investigates the potential of image analysis to quantify for the presence and extent of pulmonary hypertension secondary to sickle cell disease (SCD). A combination of fast marching and geodesic active contours level sets were employed to segment the pulmonary artery from smoothed CT-Angiography images from 16 SCD patients and 16 matching controls. An algorithm based on fast marching methods was used to compute the centerline of the segmented arteries to measure automatically the diameters of the pulmonary trunk and first branches of the pulmonary arteries. Results show that the pulmonary trunk and arterial branches are significantly larger in diameter in SCD patients as compared to controls (p-values of 0.002 for trunk and 0.0003 for branches). For validation, the results were compared with manually measured values and did not demonstrate significant difference (mean p-values 0.71). CT with image processing shows great potential as a surrogate indicator of pulmonary hemodynamics or response to therapy, which could be an important tool for drug discovery and noninvasive clinical surveillance.

AB - This retrospective study investigates the potential of image analysis to quantify for the presence and extent of pulmonary hypertension secondary to sickle cell disease (SCD). A combination of fast marching and geodesic active contours level sets were employed to segment the pulmonary artery from smoothed CT-Angiography images from 16 SCD patients and 16 matching controls. An algorithm based on fast marching methods was used to compute the centerline of the segmented arteries to measure automatically the diameters of the pulmonary trunk and first branches of the pulmonary arteries. Results show that the pulmonary trunk and arterial branches are significantly larger in diameter in SCD patients as compared to controls (p-values of 0.002 for trunk and 0.0003 for branches). For validation, the results were compared with manually measured values and did not demonstrate significant difference (mean p-values 0.71). CT with image processing shows great potential as a surrogate indicator of pulmonary hemodynamics or response to therapy, which could be an important tool for drug discovery and noninvasive clinical surveillance.

UR - http://www.scopus.com/inward/record.url?scp=84903875010&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903875010&partnerID=8YFLogxK

M3 - Article

C2 - 19162792

SP - 859

EP - 862

JO - Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference

JF - Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference

SN - 1557-170X

ER -