CT-only planning for Gamma Knife radiosurgery in the treatment of trigeminal neuralgia

Methodology and outcomes from a single institution

Albert Attia, Stephen B. Tatter, Michael Weller, Kopriva Marshall, James F. Lovato, J. Daniel Bourland, Thomas L. Ellis, Kevin P. McMullen, Edward G. Shaw, Michael D. Chan

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Introduction: Gamma Knife radiosurgery (GKRS) has been established as a safe and effective treatment option for trigeminal neuralgia. Some patients have contraindications to magnetic resonance imaging (MRI), the standard stereotactic imaging used for GKRS treatment planning. Computerized tomography (CT) imaging may be used as an alternative in this scenario. We sought to evaluate the outcomes of our patients treated using this technique. Methods: Between August 2001 and November 2009, 19 patients with trigeminal neuralgia were treated with GKRS using CT-only planning. The course of the trigeminal nerve was determined based upon anatomical landmarks when the nerve was not directly visualized on the treatment-planning CT. Median dose used was 90 Gy (range 85-90 Gy). Follow-up data based on Barrow Neurological Institute (BNI) pain score and toxicity were obtained using electronic medical records and by telephone interview. Results: With median follow-up time of 18 months (range 4-36 months), improvement in quality of life after GKRS was reported in 17 of 19 patients. Freedom from BNI IV-V pain relapse was 82% at 24 months. By 3 months post-GKRS, 50% of patients were able to discontinue medications completely. Three patients reported numbness after GKRS; none of these patients described bothersome numbness. Use of contrast did not affect treatment outcome (P = 0.31). Conclusions: Stereotactic CT-only treatment planning of GKRS for the treatment of trigeminal neuralgia is feasible and safe. Further studies are necessary to determine if the long-term durability of pain relief is comparable to that of MRI-based GKRS planning.

Original languageEnglish (US)
Pages (from-to)490-494
Number of pages5
JournalJournal of Medical Imaging and Radiation Oncology
Volume56
Issue number4
DOIs
StatePublished - Aug 2012
Externally publishedYes

Fingerprint

Trigeminal Neuralgia
Radiosurgery
Tomography
Hypesthesia
Therapeutics
Pain
Magnetic Resonance Imaging
Trigeminal Nerve
Electronic Health Records
Quality of Life
Interviews
Recurrence

Keywords

  • computerized tomography
  • Gamma Knife
  • magnetic resonance imaging
  • radiosurgery
  • trigeminal neuralgia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Oncology

Cite this

CT-only planning for Gamma Knife radiosurgery in the treatment of trigeminal neuralgia : Methodology and outcomes from a single institution. / Attia, Albert; Tatter, Stephen B.; Weller, Michael; Marshall, Kopriva; Lovato, James F.; Bourland, J. Daniel; Ellis, Thomas L.; McMullen, Kevin P.; Shaw, Edward G.; Chan, Michael D.

In: Journal of Medical Imaging and Radiation Oncology, Vol. 56, No. 4, 08.2012, p. 490-494.

Research output: Contribution to journalArticle

Attia, A, Tatter, SB, Weller, M, Marshall, K, Lovato, JF, Bourland, JD, Ellis, TL, McMullen, KP, Shaw, EG & Chan, MD 2012, 'CT-only planning for Gamma Knife radiosurgery in the treatment of trigeminal neuralgia: Methodology and outcomes from a single institution', Journal of Medical Imaging and Radiation Oncology, vol. 56, no. 4, pp. 490-494. https://doi.org/10.1111/j.1754-9485.2012.02403.x
Attia, Albert ; Tatter, Stephen B. ; Weller, Michael ; Marshall, Kopriva ; Lovato, James F. ; Bourland, J. Daniel ; Ellis, Thomas L. ; McMullen, Kevin P. ; Shaw, Edward G. ; Chan, Michael D. / CT-only planning for Gamma Knife radiosurgery in the treatment of trigeminal neuralgia : Methodology and outcomes from a single institution. In: Journal of Medical Imaging and Radiation Oncology. 2012 ; Vol. 56, No. 4. pp. 490-494.
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abstract = "Introduction: Gamma Knife radiosurgery (GKRS) has been established as a safe and effective treatment option for trigeminal neuralgia. Some patients have contraindications to magnetic resonance imaging (MRI), the standard stereotactic imaging used for GKRS treatment planning. Computerized tomography (CT) imaging may be used as an alternative in this scenario. We sought to evaluate the outcomes of our patients treated using this technique. Methods: Between August 2001 and November 2009, 19 patients with trigeminal neuralgia were treated with GKRS using CT-only planning. The course of the trigeminal nerve was determined based upon anatomical landmarks when the nerve was not directly visualized on the treatment-planning CT. Median dose used was 90 Gy (range 85-90 Gy). Follow-up data based on Barrow Neurological Institute (BNI) pain score and toxicity were obtained using electronic medical records and by telephone interview. Results: With median follow-up time of 18 months (range 4-36 months), improvement in quality of life after GKRS was reported in 17 of 19 patients. Freedom from BNI IV-V pain relapse was 82{\%} at 24 months. By 3 months post-GKRS, 50{\%} of patients were able to discontinue medications completely. Three patients reported numbness after GKRS; none of these patients described bothersome numbness. Use of contrast did not affect treatment outcome (P = 0.31). Conclusions: Stereotactic CT-only treatment planning of GKRS for the treatment of trigeminal neuralgia is feasible and safe. Further studies are necessary to determine if the long-term durability of pain relief is comparable to that of MRI-based GKRS planning.",
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AU - Weller, Michael

AU - Marshall, Kopriva

AU - Lovato, James F.

AU - Bourland, J. Daniel

AU - Ellis, Thomas L.

AU - McMullen, Kevin P.

AU - Shaw, Edward G.

AU - Chan, Michael D.

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N2 - Introduction: Gamma Knife radiosurgery (GKRS) has been established as a safe and effective treatment option for trigeminal neuralgia. Some patients have contraindications to magnetic resonance imaging (MRI), the standard stereotactic imaging used for GKRS treatment planning. Computerized tomography (CT) imaging may be used as an alternative in this scenario. We sought to evaluate the outcomes of our patients treated using this technique. Methods: Between August 2001 and November 2009, 19 patients with trigeminal neuralgia were treated with GKRS using CT-only planning. The course of the trigeminal nerve was determined based upon anatomical landmarks when the nerve was not directly visualized on the treatment-planning CT. Median dose used was 90 Gy (range 85-90 Gy). Follow-up data based on Barrow Neurological Institute (BNI) pain score and toxicity were obtained using electronic medical records and by telephone interview. Results: With median follow-up time of 18 months (range 4-36 months), improvement in quality of life after GKRS was reported in 17 of 19 patients. Freedom from BNI IV-V pain relapse was 82% at 24 months. By 3 months post-GKRS, 50% of patients were able to discontinue medications completely. Three patients reported numbness after GKRS; none of these patients described bothersome numbness. Use of contrast did not affect treatment outcome (P = 0.31). Conclusions: Stereotactic CT-only treatment planning of GKRS for the treatment of trigeminal neuralgia is feasible and safe. Further studies are necessary to determine if the long-term durability of pain relief is comparable to that of MRI-based GKRS planning.

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KW - Gamma Knife

KW - magnetic resonance imaging

KW - radiosurgery

KW - trigeminal neuralgia

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