CT patterns of intracranial hemorrhage complicating thrombolytic therapy for acute myocardial infarction

John P. Uglietla, Christopher M. O'Connor, Orest Boyko, Harry Aldrich, Edward W. Massey, E. Ralph Heinz

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Computed tomographic (CT) patterns intracranial hemorrhage (ICH) were determined in 1,696 patients undergoing thrombolytic therapy for acute myocardial infarction. ICH occurred at 33 sites in 0.77% of patients (n = 13). Thirty-six percent of hemorrhages (n = 12) were intraparenchymal, 33% (n = 11) were subdural, 24% (n = 8) were subarachnoid, and 6% (n = 2) were intraventricular. Eighty-four percent (n = 26) of all nonventricular hemorrhages were supratentorial in location. The most common site of ICH was supratentorial and intraparenchymal (10 of 33). In 11 of the 13 patients with ICH, clinical symptoms occurred within 24 hours of the initiation of thrombolytic therapy. A fatal outcome resulted in three of the four patients who had clinical symptoms within 3.5 hours after beginning thrombolytic therapy. The CT findings of multiple intracranial bleeding sites, substantial mass effect with midline shift, and large-volume intraparenchymal hematomas were associated with increased mortality. ICH associated with thrombolytic therapy for acute myocardial infarction has a grave prognosis, with 62% of patients dying during hospitalization.

Original languageEnglish (US)
Pages (from-to)555-559
Number of pages5
JournalRadiology
Volume181
Issue number2
StatePublished - Nov 1991
Externally publishedYes

Fingerprint

Intracranial Hemorrhages
Thrombolytic Therapy
Myocardial Infarction
Hemorrhage
Fatal Outcome
Hematoma
Hospitalization
Mortality

Keywords

  • Brain, CT, 13.1211, 15.1211
  • Brain, hemorrhage, 13.367, 15.367
  • Myocardium, infarction, 511.771
  • Thrombolysis

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Uglietla, J. P., O'Connor, C. M., Boyko, O., Aldrich, H., Massey, E. W., & Heinz, E. R. (1991). CT patterns of intracranial hemorrhage complicating thrombolytic therapy for acute myocardial infarction. Radiology, 181(2), 555-559.

CT patterns of intracranial hemorrhage complicating thrombolytic therapy for acute myocardial infarction. / Uglietla, John P.; O'Connor, Christopher M.; Boyko, Orest; Aldrich, Harry; Massey, Edward W.; Heinz, E. Ralph.

In: Radiology, Vol. 181, No. 2, 11.1991, p. 555-559.

Research output: Contribution to journalArticle

Uglietla, JP, O'Connor, CM, Boyko, O, Aldrich, H, Massey, EW & Heinz, ER 1991, 'CT patterns of intracranial hemorrhage complicating thrombolytic therapy for acute myocardial infarction', Radiology, vol. 181, no. 2, pp. 555-559.
Uglietla JP, O'Connor CM, Boyko O, Aldrich H, Massey EW, Heinz ER. CT patterns of intracranial hemorrhage complicating thrombolytic therapy for acute myocardial infarction. Radiology. 1991 Nov;181(2):555-559.
Uglietla, John P. ; O'Connor, Christopher M. ; Boyko, Orest ; Aldrich, Harry ; Massey, Edward W. ; Heinz, E. Ralph. / CT patterns of intracranial hemorrhage complicating thrombolytic therapy for acute myocardial infarction. In: Radiology. 1991 ; Vol. 181, No. 2. pp. 555-559.
@article{f95f76c1d1d744b4ba916b0bf643f5c6,
title = "CT patterns of intracranial hemorrhage complicating thrombolytic therapy for acute myocardial infarction",
abstract = "Computed tomographic (CT) patterns intracranial hemorrhage (ICH) were determined in 1,696 patients undergoing thrombolytic therapy for acute myocardial infarction. ICH occurred at 33 sites in 0.77{\%} of patients (n = 13). Thirty-six percent of hemorrhages (n = 12) were intraparenchymal, 33{\%} (n = 11) were subdural, 24{\%} (n = 8) were subarachnoid, and 6{\%} (n = 2) were intraventricular. Eighty-four percent (n = 26) of all nonventricular hemorrhages were supratentorial in location. The most common site of ICH was supratentorial and intraparenchymal (10 of 33). In 11 of the 13 patients with ICH, clinical symptoms occurred within 24 hours of the initiation of thrombolytic therapy. A fatal outcome resulted in three of the four patients who had clinical symptoms within 3.5 hours after beginning thrombolytic therapy. The CT findings of multiple intracranial bleeding sites, substantial mass effect with midline shift, and large-volume intraparenchymal hematomas were associated with increased mortality. ICH associated with thrombolytic therapy for acute myocardial infarction has a grave prognosis, with 62{\%} of patients dying during hospitalization.",
keywords = "Brain, CT, 13.1211, 15.1211, Brain, hemorrhage, 13.367, 15.367, Myocardium, infarction, 511.771, Thrombolysis",
author = "Uglietla, {John P.} and O'Connor, {Christopher M.} and Orest Boyko and Harry Aldrich and Massey, {Edward W.} and Heinz, {E. Ralph}",
year = "1991",
month = "11",
language = "English (US)",
volume = "181",
pages = "555--559",
journal = "Radiology",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "2",

}

TY - JOUR

T1 - CT patterns of intracranial hemorrhage complicating thrombolytic therapy for acute myocardial infarction

AU - Uglietla, John P.

AU - O'Connor, Christopher M.

AU - Boyko, Orest

AU - Aldrich, Harry

AU - Massey, Edward W.

AU - Heinz, E. Ralph

PY - 1991/11

Y1 - 1991/11

N2 - Computed tomographic (CT) patterns intracranial hemorrhage (ICH) were determined in 1,696 patients undergoing thrombolytic therapy for acute myocardial infarction. ICH occurred at 33 sites in 0.77% of patients (n = 13). Thirty-six percent of hemorrhages (n = 12) were intraparenchymal, 33% (n = 11) were subdural, 24% (n = 8) were subarachnoid, and 6% (n = 2) were intraventricular. Eighty-four percent (n = 26) of all nonventricular hemorrhages were supratentorial in location. The most common site of ICH was supratentorial and intraparenchymal (10 of 33). In 11 of the 13 patients with ICH, clinical symptoms occurred within 24 hours of the initiation of thrombolytic therapy. A fatal outcome resulted in three of the four patients who had clinical symptoms within 3.5 hours after beginning thrombolytic therapy. The CT findings of multiple intracranial bleeding sites, substantial mass effect with midline shift, and large-volume intraparenchymal hematomas were associated with increased mortality. ICH associated with thrombolytic therapy for acute myocardial infarction has a grave prognosis, with 62% of patients dying during hospitalization.

AB - Computed tomographic (CT) patterns intracranial hemorrhage (ICH) were determined in 1,696 patients undergoing thrombolytic therapy for acute myocardial infarction. ICH occurred at 33 sites in 0.77% of patients (n = 13). Thirty-six percent of hemorrhages (n = 12) were intraparenchymal, 33% (n = 11) were subdural, 24% (n = 8) were subarachnoid, and 6% (n = 2) were intraventricular. Eighty-four percent (n = 26) of all nonventricular hemorrhages were supratentorial in location. The most common site of ICH was supratentorial and intraparenchymal (10 of 33). In 11 of the 13 patients with ICH, clinical symptoms occurred within 24 hours of the initiation of thrombolytic therapy. A fatal outcome resulted in three of the four patients who had clinical symptoms within 3.5 hours after beginning thrombolytic therapy. The CT findings of multiple intracranial bleeding sites, substantial mass effect with midline shift, and large-volume intraparenchymal hematomas were associated with increased mortality. ICH associated with thrombolytic therapy for acute myocardial infarction has a grave prognosis, with 62% of patients dying during hospitalization.

KW - Brain, CT, 13.1211, 15.1211

KW - Brain, hemorrhage, 13.367, 15.367

KW - Myocardium, infarction, 511.771

KW - Thrombolysis

UR - http://www.scopus.com/inward/record.url?scp=0025991473&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025991473&partnerID=8YFLogxK

M3 - Article

C2 - 1924804

AN - SCOPUS:0025991473

VL - 181

SP - 555

EP - 559

JO - Radiology

JF - Radiology

SN - 0033-8419

IS - 2

ER -