Cue-dependent inhibition in posttraumatic stress disorder and attention-deficit/hyperactivity disorder

Zachary W. Adams, Michael Meinzer, Howard Mandel, Joshua Voltin, Blaine Caughron, Floyd R. Sallee, Mark Hamner, Zhewu Wang

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Objective Attention-deficit/hyperactivity disorder (ADHD) and posttraumatic stress disorder (PTSD) are common among military veterans, but the comorbidity of these two psychiatric disorders remains largely unstudied. Evaluating response inhibition and cue-dependent learning as behavioral and neurocognitive mechanisms underlying ADHD/PTSD can inform etiological models and development of tailored interventions. Method A cued go/no-go task evaluated response inhibition in 160 adult males. Participants were recruited from the community and a Veterans Administration medical center. Four diagnostic groups were identified: ADHD-only, PTSD-only, ADHD + PTSD, controls. Results Group differences were observed across most indices of inhibitory functioning, reaction time, and reaction time variability, whereby PTSD-only and ADHD + PTSD participants demonstrated deficits relative to controls. No cue dependency effects were observed. Conclusion Finding complement prior work on neurocognitive mechanisms underlying ADHD, PTSD, and ADHD + PTSD. Lack of expected group differences for the ADHD-only group may be due to limited power. Additional work is needed to better characterize distinctions among clinical groups, as well as to test effects among women and youth.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalJournal of Anxiety Disorders
StatePublished - Oct 2017


  • ADHD
  • Comorbidity
  • Cued reaction time task
  • Executive functioning
  • PTSD
  • Response inhibition

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

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