Culture medium oxygen tension affects fibronectin production in human adult and cord blood macrophages

Mervin Yoder, T. A. Lanker, W. A. Engle

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Varying culture medium oxygen tension from one-half to twice the normal concentration did not alter adult or cord blood monocyte-derived macrophage secretion of lysozyme or total protein. Lowering oxygen tension did result in significant increases in fibronectin concentration in both adult and cord blood macrophage culture supernatants. Dexamethasone (10-7 M) completely blocked adult macrophage but had no effect on cord blood macrophage fibronectin release in response to lowering oxygen tension. These results indicate that human macrophages selectively regulate fibronectin production in response to changes in oxygen tension in vitro.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalImmunology Letters
Volume19
Issue number1
DOIs
StatePublished - 1988

Fingerprint

Fetal Blood
Fibronectins
Culture Media
Macrophages
Oxygen
Muramidase
Dexamethasone
Proteins

Keywords

  • Cord blood
  • Culture
  • Fibronectin
  • Macrophage
  • Oxygen tension

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Culture medium oxygen tension affects fibronectin production in human adult and cord blood macrophages. / Yoder, Mervin; Lanker, T. A.; Engle, W. A.

In: Immunology Letters, Vol. 19, No. 1, 1988, p. 1-6.

Research output: Contribution to journalArticle

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