Cumulative ultraviolet radiation flux in adulthood and risk of incident skin cancers in women

S. Wu, J. Han, R. A. Vleugels, R. Puett, F. Laden, D. J. Hunter, A. A. Qureshi

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Background:Solar ultraviolet (UV) exposure estimated based on residential history has been used as a sun exposure indicator in previous case-control and descriptive studies. However, the associations of cumulative UV exposure based on residential history with different skin cancers, including melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC), have not been evaluated simultaneously in prospective studies.Methods:We conducted a cohort study among 108 578 women in the Nurses' Health Study (1976-2006) to evaluate the relative risks of skin cancers with cumulative UV flux based on residential history in adulthood.Results:Risk of SCC and BCC was significantly lower for women in lower quintiles vs the highest quintile of cumulative UV flux (both P for trend <0.0001). The association between cumulative UV flux and risk of melanoma did not reach statistical significance. However, risk of melanoma appeared to be lower among women in lower quintiles vs the highest quintile of cumulative UV flux in lag analyses with 2-10 years between exposure and outcome. The multivariable-adjusted hazard ratios per 200 × 10-4 Robertson-Berger units increase in cumulative UV flux were 0.979 (95% confidence interval (CI): 0.933, 1.028) for melanoma, 1.072 (95% CI: 1.041, 1.103) for SCC, and 1.043 (95% CI: 1.034, 1.052) for BCC.Conclusions:Associations with cumulative UV exposure in adulthood among women differed for melanoma, SCC, and BCC, suggesting a potential variable role of UV radiation in adulthood in the carcinogenesis of the three major skin cancers.

Original languageEnglish (US)
Pages (from-to)1855-1861
Number of pages7
JournalBritish Journal of Cancer
Volume110
Issue number7
DOIs
StatePublished - Apr 1 2014

Keywords

  • basal cell carcinoma
  • melanoma
  • residential history
  • skin cancer
  • squamous cell carcinoma
  • ultraviolet

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Wu, S., Han, J., Vleugels, R. A., Puett, R., Laden, F., Hunter, D. J., & Qureshi, A. A. (2014). Cumulative ultraviolet radiation flux in adulthood and risk of incident skin cancers in women. British Journal of Cancer, 110(7), 1855-1861. https://doi.org/10.1038/bjc.2014.43