Current development of collagen-based biomaterials for tissue repair and regeneration

Adam J.P. Bauer, Jianzhao Liu, L. Jack Windsor, Fengyu Song, Bingbing Li

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Collagens, especially Type I collagen, are the primary structural proteins in the body. They sustain mechanical bodily stresses, support different types of cells, and serve as anchors for various growth factors. The collagen-peptides produced when collagens are cleaved by enzymatic activities also exhibit potent biological activities. As highly biocompatible molecules with potent biological functions, the collagens have garnered wide interest as biomedical materials, in particular, for tissue repair and regeneration. This review first provides a brief introduction to collagen structure and classification, and then primarily focuses on the current development of collagen-based biomaterials, with emphasis on collagen-based scaffolding materials for tissue regeneration.

Original languageEnglish (US)
Pages (from-to)359-370
Number of pages12
JournalSoft Materials
Volume12
Issue number4
DOIs
StatePublished - Oct 13 2014

Keywords

  • Biomaterials
  • Collagen
  • Electrospinning
  • Regenerative medicine
  • Tissue engineering

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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