Current perspectives of the roles of the central norepinephrine system in anxiety and depression

Andrew W. Goddard, Susan G. Ball, James Martinez, Michael J. Robinson, Charles R. Yang, James M. Russell, Anantha Shekhar

Research output: Contribution to journalArticle

127 Citations (Scopus)

Abstract

Norepinephrine (NE) is a major monoamine neurotransmitter that has widespread effects across multiple brain areas to regulate arousal and stress responses. The underlying function of the NE cortical system is to balance vigilance/scanning behavior with focused attention on novel environmental stimuli and the state of arousal. The central NE system is involved intrinsically with the stress response system, and dysregulation within the NE system has been implicated in the pathogenesis of anxiety and depressive disorders. Central NE activity paradoxically has either anxiogenic or anxiolytic effects, depending on whether the time course of the stress is acute or chronic, whether the stress is predictable or unpredictable, and which underlying brain regions are affected. Under conditions of chronic stress, NE system activity dysregulation of the hypothalamic-pituitary-adrenal system may turn a homeostatic stress response into a pathological stress response. Data suggest that the NE interplay with the serotonin system may exert neurobiological normalization of the pathophysiological state of anxious depression. Accordingly, pharmacological interventions targeting the NE system can result in anxiolytic, rather than anxiogenic, outcomes when used to treat patients with anxiety and depression.

Original languageEnglish
Pages (from-to)339-350
Number of pages12
JournalDepression and Anxiety
Volume27
Issue number4
DOIs
StatePublished - Apr 2010

Fingerprint

Norepinephrine
Anxiety
Depression
Anti-Anxiety Agents
Arousal
Pituitary-Adrenal System
Brain
Depressive Disorder
Anxiety Disorders
Neurotransmitter Agents
Serotonin
Pharmacology

Keywords

  • Anxious
  • Neurobiology
  • Norepinephrine transporter
  • Pharmacotherapy
  • Stress

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Goddard, A. W., Ball, S. G., Martinez, J., Robinson, M. J., Yang, C. R., Russell, J. M., & Shekhar, A. (2010). Current perspectives of the roles of the central norepinephrine system in anxiety and depression. Depression and Anxiety, 27(4), 339-350. https://doi.org/10.1002/da.20642

Current perspectives of the roles of the central norepinephrine system in anxiety and depression. / Goddard, Andrew W.; Ball, Susan G.; Martinez, James; Robinson, Michael J.; Yang, Charles R.; Russell, James M.; Shekhar, Anantha.

In: Depression and Anxiety, Vol. 27, No. 4, 04.2010, p. 339-350.

Research output: Contribution to journalArticle

Goddard, AW, Ball, SG, Martinez, J, Robinson, MJ, Yang, CR, Russell, JM & Shekhar, A 2010, 'Current perspectives of the roles of the central norepinephrine system in anxiety and depression', Depression and Anxiety, vol. 27, no. 4, pp. 339-350. https://doi.org/10.1002/da.20642
Goddard AW, Ball SG, Martinez J, Robinson MJ, Yang CR, Russell JM et al. Current perspectives of the roles of the central norepinephrine system in anxiety and depression. Depression and Anxiety. 2010 Apr;27(4):339-350. https://doi.org/10.1002/da.20642
Goddard, Andrew W. ; Ball, Susan G. ; Martinez, James ; Robinson, Michael J. ; Yang, Charles R. ; Russell, James M. ; Shekhar, Anantha. / Current perspectives of the roles of the central norepinephrine system in anxiety and depression. In: Depression and Anxiety. 2010 ; Vol. 27, No. 4. pp. 339-350.
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