Current status of pig liver xenotransplantation

Burcin Ekser, James F. Markmann, A. Joseph Tector

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The shortage of organs from deceased human donors is a major problem limiting the number of organs transplanted each year and results in the death of thousands of patients on the waiting list. Pigs are currently the preferred species for clinical organ xenotransplantation. Progress in genetically-engineered (GE) pig liver xenotransplantation increased graft and recipient survival from hours with unmodified pig livers to up to 9 days with normal to near-normal liver function. Deletion of genes such as GGTA1 (Gal-knockout pigs) or adding genes such as human complement regulatory proteins (hCD55, hCD46 expressing pigs) enabled hyperacute rejection to be overcome. Although survival up to 9 days was recorded, extended pig graft survival was not achieved due to lethal thrombocytopenia. The current status of GE pig liver xenotransplantation with world experience, potential factors causing thrombocytopenia, new targets on pig endothelial cells, and novel GE pigs with more genes deletion to avoid remaining antibody response, such as beta1,4-N-acetyl galactosaminyl transferase 2 (β4GalNT2), are discussed.

Original languageEnglish (US)
Pages (from-to)240-246
Number of pages7
JournalInternational Journal of Surgery
Volume23
DOIs
StatePublished - Nov 1 2015

Fingerprint

Heterologous Transplantation
Swine
Liver
Gene Deletion
Graft Survival
Thrombocytopenia
Waiting Lists
Transferases
Antibody Formation
Complement System Proteins
Endothelial Cells
Tissue Donors
Survival

Keywords

  • Acute liver failure
  • Liver
  • Nonhuman primate
  • Pig
  • Xenotransplantation

ASJC Scopus subject areas

  • Surgery

Cite this

Current status of pig liver xenotransplantation. / Ekser, Burcin; Markmann, James F.; Tector, A. Joseph.

In: International Journal of Surgery, Vol. 23, 01.11.2015, p. 240-246.

Research output: Contribution to journalArticle

Ekser, Burcin ; Markmann, James F. ; Tector, A. Joseph. / Current status of pig liver xenotransplantation. In: International Journal of Surgery. 2015 ; Vol. 23. pp. 240-246.
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