Cutaneous presentation of juvenile chronic myelogenous leukemia

A diagnostic and therapeutic dilemma

U. I. Sires, S. B. Mallory, Jay Hess, J. P. Keating, G. Bloomberg, L. P. Dehner

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Annular, erythematous, circinate plaques were the first manifestation of juvenile chronic myelogenous leukemia (JCML) in an otherwise healthy 2.5- year-old boy who had had these lesions since 6 months of age. The lesions showed an atypical hematopoietic infiltrate on biopsy. Biopsy of a bone marrow specimen and peripheral blood smear were normal six months before leukemic transformation. At 3 years of age the boy developed splenomegaly, thrombocytopenia, and petechiae, and a bone marrow aspirate and cell marker studies were regarded as consistent with, if not diagnostic of, JCML. Four previous cases of cutaneous leukemic infiltrate associated with JCML have been published. Our patient had recurring urticarial-like plaques for two years before the initial bone marrow finding of JCML. Given the poor prognosis and progressively evolving course of JCML, it may be appropriate to consider therapy before bone marrow changes, based on the presence of the cutaneous eruption with the appropriate findings on skin biopsy and an elevated fetal hemoglobin.

Original languageEnglish (US)
Pages (from-to)364-368
Number of pages5
JournalPediatric Dermatology
Volume12
Issue number4
StatePublished - 1995
Externally publishedYes

Fingerprint

Juvenile Myelomonocytic Leukemia
Skin
Bone Marrow
Biopsy
Therapeutics
Fetal Hemoglobin
Purpura
Splenomegaly
Bone Marrow Cells
Thrombocytopenia

ASJC Scopus subject areas

  • Dermatology
  • Pediatrics, Perinatology, and Child Health

Cite this

Sires, U. I., Mallory, S. B., Hess, J., Keating, J. P., Bloomberg, G., & Dehner, L. P. (1995). Cutaneous presentation of juvenile chronic myelogenous leukemia: A diagnostic and therapeutic dilemma. Pediatric Dermatology, 12(4), 364-368.

Cutaneous presentation of juvenile chronic myelogenous leukemia : A diagnostic and therapeutic dilemma. / Sires, U. I.; Mallory, S. B.; Hess, Jay; Keating, J. P.; Bloomberg, G.; Dehner, L. P.

In: Pediatric Dermatology, Vol. 12, No. 4, 1995, p. 364-368.

Research output: Contribution to journalArticle

Sires, UI, Mallory, SB, Hess, J, Keating, JP, Bloomberg, G & Dehner, LP 1995, 'Cutaneous presentation of juvenile chronic myelogenous leukemia: A diagnostic and therapeutic dilemma', Pediatric Dermatology, vol. 12, no. 4, pp. 364-368.
Sires, U. I. ; Mallory, S. B. ; Hess, Jay ; Keating, J. P. ; Bloomberg, G. ; Dehner, L. P. / Cutaneous presentation of juvenile chronic myelogenous leukemia : A diagnostic and therapeutic dilemma. In: Pediatric Dermatology. 1995 ; Vol. 12, No. 4. pp. 364-368.
@article{f416953b4bc2422c8d9e688031536310,
title = "Cutaneous presentation of juvenile chronic myelogenous leukemia: A diagnostic and therapeutic dilemma",
abstract = "Annular, erythematous, circinate plaques were the first manifestation of juvenile chronic myelogenous leukemia (JCML) in an otherwise healthy 2.5- year-old boy who had had these lesions since 6 months of age. The lesions showed an atypical hematopoietic infiltrate on biopsy. Biopsy of a bone marrow specimen and peripheral blood smear were normal six months before leukemic transformation. At 3 years of age the boy developed splenomegaly, thrombocytopenia, and petechiae, and a bone marrow aspirate and cell marker studies were regarded as consistent with, if not diagnostic of, JCML. Four previous cases of cutaneous leukemic infiltrate associated with JCML have been published. Our patient had recurring urticarial-like plaques for two years before the initial bone marrow finding of JCML. Given the poor prognosis and progressively evolving course of JCML, it may be appropriate to consider therapy before bone marrow changes, based on the presence of the cutaneous eruption with the appropriate findings on skin biopsy and an elevated fetal hemoglobin.",
author = "Sires, {U. I.} and Mallory, {S. B.} and Jay Hess and Keating, {J. P.} and G. Bloomberg and Dehner, {L. P.}",
year = "1995",
language = "English (US)",
volume = "12",
pages = "364--368",
journal = "Pediatric Dermatology",
issn = "0736-8046",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Cutaneous presentation of juvenile chronic myelogenous leukemia

T2 - A diagnostic and therapeutic dilemma

AU - Sires, U. I.

AU - Mallory, S. B.

AU - Hess, Jay

AU - Keating, J. P.

AU - Bloomberg, G.

AU - Dehner, L. P.

PY - 1995

Y1 - 1995

N2 - Annular, erythematous, circinate plaques were the first manifestation of juvenile chronic myelogenous leukemia (JCML) in an otherwise healthy 2.5- year-old boy who had had these lesions since 6 months of age. The lesions showed an atypical hematopoietic infiltrate on biopsy. Biopsy of a bone marrow specimen and peripheral blood smear were normal six months before leukemic transformation. At 3 years of age the boy developed splenomegaly, thrombocytopenia, and petechiae, and a bone marrow aspirate and cell marker studies were regarded as consistent with, if not diagnostic of, JCML. Four previous cases of cutaneous leukemic infiltrate associated with JCML have been published. Our patient had recurring urticarial-like plaques for two years before the initial bone marrow finding of JCML. Given the poor prognosis and progressively evolving course of JCML, it may be appropriate to consider therapy before bone marrow changes, based on the presence of the cutaneous eruption with the appropriate findings on skin biopsy and an elevated fetal hemoglobin.

AB - Annular, erythematous, circinate plaques were the first manifestation of juvenile chronic myelogenous leukemia (JCML) in an otherwise healthy 2.5- year-old boy who had had these lesions since 6 months of age. The lesions showed an atypical hematopoietic infiltrate on biopsy. Biopsy of a bone marrow specimen and peripheral blood smear were normal six months before leukemic transformation. At 3 years of age the boy developed splenomegaly, thrombocytopenia, and petechiae, and a bone marrow aspirate and cell marker studies were regarded as consistent with, if not diagnostic of, JCML. Four previous cases of cutaneous leukemic infiltrate associated with JCML have been published. Our patient had recurring urticarial-like plaques for two years before the initial bone marrow finding of JCML. Given the poor prognosis and progressively evolving course of JCML, it may be appropriate to consider therapy before bone marrow changes, based on the presence of the cutaneous eruption with the appropriate findings on skin biopsy and an elevated fetal hemoglobin.

UR - http://www.scopus.com/inward/record.url?scp=0029565053&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029565053&partnerID=8YFLogxK

M3 - Article

VL - 12

SP - 364

EP - 368

JO - Pediatric Dermatology

JF - Pediatric Dermatology

SN - 0736-8046

IS - 4

ER -