Cutaneous Presentation of Juvenile Chronic Myelogenous Leukemia: A Diagnostic and Therapeutic Dilemma

Ulrike I. Sires, Susan B. Mallory, Jay L. Hess, James P. Keating, Gordon Bloomberg, Louis P. Dehner

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Abstract: Annular, erythematous, circinate plaques were the first manifestation of juvenile chronic myelogenous leukemia (JCML) in an otherwise healthy 2.5‐year‐old boy who had had these lesions since 6 months of age. The lesions showed an atypical hematopoietic infiltrate on biopsy. Biopsy of a bone marrow specimen and peripheral blood smear were normal six months before leukemic transformation. At 3 years of age the boy developed splenomegaly, thrombocytopenia, and petechiae, and a bone marrow aspirate and cell marker studies were regarded as consistent with, if not diagnostic of, JCML. Four previous cases of cutaneous leukemic infiltrate associated with JCML have been published. Our patient had recurring urticarial‐like plaques for two years before the initial bone marrow finding of JCML. Given the poor prognosis and progressively evolving course of JCML, it may be appropriate to consider therapy before bone marrow changes, based on the presence of the cutaneous eruption with the appropriate findings on skin biopsy and an elevated fetal hemoglobin.

Original languageEnglish (US)
Pages (from-to)364-368
Number of pages5
JournalPediatric Dermatology
Volume12
Issue number4
DOIs
StatePublished - Dec 1995
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Dermatology

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