Cutting edge: Differential expression of chemokines in Th1 and Th2 cells is dependent on Stat6 but not Stat4

Shangming Zhang, Nicholas W. Lukacs, Victoria A. Lawless, Steven L. Kunkel, Mark H. Kaplan

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

The in vivo function of Th sell subsets is largely dependent on the ability of differentiated CD4+ T cells to be recruited to specific sites and secrete restricted sets of cytokines. In this paper we demonstrate that Th1 and Th2 cells secrete discrete patterns of chemokines, small m.w. cytokines that function as chemoattractants in inflammatory reactions. Th2 cells secrete and acquisition of this pattern of expression is dependent on Stat6. In contrast, Th1 cells secrete lymphotactin and RANTES, though unlike IFN-γ, expression of these chemokines is independent Stat4. We further show that supernatants from activated Th2 cells preferentially induce the chemotaxis of Th2 over Th1-cells, corresponding with Stat6-dependent expression of CCR4 and CCR8 in Th2 cells. These data provide the basis for restricted and direct T cell-mediated cellular recruitment to sites of inflammation.

Original languageEnglish (US)
Pages (from-to)10-14
Number of pages5
JournalJournal of Immunology
Volume165
Issue number1
DOIs
StatePublished - Jul 1 2000

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Th2 Cells
Th1 Cells
Chemokines
Cytokines
T-Lymphocytes
Chemokine CCL5
Aptitude
Chemotactic Factors
Chemotaxis
Inflammation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Cutting edge : Differential expression of chemokines in Th1 and Th2 cells is dependent on Stat6 but not Stat4. / Zhang, Shangming; Lukacs, Nicholas W.; Lawless, Victoria A.; Kunkel, Steven L.; Kaplan, Mark H.

In: Journal of Immunology, Vol. 165, No. 1, 01.07.2000, p. 10-14.

Research output: Contribution to journalArticle

Zhang, Shangming ; Lukacs, Nicholas W. ; Lawless, Victoria A. ; Kunkel, Steven L. ; Kaplan, Mark H. / Cutting edge : Differential expression of chemokines in Th1 and Th2 cells is dependent on Stat6 but not Stat4. In: Journal of Immunology. 2000 ; Vol. 165, No. 1. pp. 10-14.
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