Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis

Trevor Starnes, Hal E. Broxmeyer, Michael J. Robertson, Robert Hromas

Research output: Contribution to journalArticle

197 Scopus citations

Abstract

A novel cytokine termed IL-17D was cloned using nested RACE PCR. It is a secreted cytokine with homology to the IL-17 family of proteins. IL-17D is preferentially expressed in skeletal muscle, brain, adipose tissue, heart, lung, and pancreas. Treatment of endothelial cells with purified rIL-17D protein stimulated the production of IL-6, IL-8, and GM-CSF. The increased expression of IL-8 was found to be NF-κB-dependent. rIL-17D also demonstrated an inhibitory effect on hemopoiesis of myeloid progenitor cells in colony formation assays.

Original languageEnglish (US)
Pages (from-to)642-646
Number of pages5
JournalJournal of Immunology
Volume169
Issue number2
DOIs
StatePublished - Jul 15 2002

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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