Abstract
A novel cytokine termed IL-17D was cloned using nested RACE PCR. It is a secreted cytokine with homology to the IL-17 family of proteins. IL-17D is preferentially expressed in skeletal muscle, brain, adipose tissue, heart, lung, and pancreas. Treatment of endothelial cells with purified rIL-17D protein stimulated the production of IL-6, IL-8, and GM-CSF. The increased expression of IL-8 was found to be NF-κB-dependent. rIL-17D also demonstrated an inhibitory effect on hemopoiesis of myeloid progenitor cells in colony formation assays.
| Original language | English |
|---|---|
| Pages (from-to) | 642-646 |
| Number of pages | 5 |
| Journal | Journal of Immunology |
| Volume | 169 |
| Issue number | 2 |
| State | Published - Jul 15 2002 |
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ASJC Scopus subject areas
- Immunology
Cite this
Cutting edge : IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis. / Starnes, Trevor; Broxmeyer, Hal; Robertson, Michael; Hromas, Robert.
In: Journal of Immunology, Vol. 169, No. 2, 15.07.2002, p. 642-646.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cutting edge
T2 - IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis
AU - Starnes, Trevor
AU - Broxmeyer, Hal
AU - Robertson, Michael
AU - Hromas, Robert
PY - 2002/7/15
Y1 - 2002/7/15
N2 - A novel cytokine termed IL-17D was cloned using nested RACE PCR. It is a secreted cytokine with homology to the IL-17 family of proteins. IL-17D is preferentially expressed in skeletal muscle, brain, adipose tissue, heart, lung, and pancreas. Treatment of endothelial cells with purified rIL-17D protein stimulated the production of IL-6, IL-8, and GM-CSF. The increased expression of IL-8 was found to be NF-κB-dependent. rIL-17D also demonstrated an inhibitory effect on hemopoiesis of myeloid progenitor cells in colony formation assays.
AB - A novel cytokine termed IL-17D was cloned using nested RACE PCR. It is a secreted cytokine with homology to the IL-17 family of proteins. IL-17D is preferentially expressed in skeletal muscle, brain, adipose tissue, heart, lung, and pancreas. Treatment of endothelial cells with purified rIL-17D protein stimulated the production of IL-6, IL-8, and GM-CSF. The increased expression of IL-8 was found to be NF-κB-dependent. rIL-17D also demonstrated an inhibitory effect on hemopoiesis of myeloid progenitor cells in colony formation assays.
UR - http://www.scopus.com/inward/record.url?scp=0037100263&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037100263&partnerID=8YFLogxK
M3 - Article
C2 - 12097364
AN - SCOPUS:0037100263
VL - 169
SP - 642
EP - 646
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 2
ER -