Abstract
A novel cytokine termed IL-17D was cloned using nested RACE PCR. It is a secreted cytokine with homology to the IL-17 family of proteins. IL-17D is preferentially expressed in skeletal muscle, brain, adipose tissue, heart, lung, and pancreas. Treatment of endothelial cells with purified rIL-17D protein stimulated the production of IL-6, IL-8, and GM-CSF. The increased expression of IL-8 was found to be NF-κB-dependent. rIL-17D also demonstrated an inhibitory effect on hemopoiesis of myeloid progenitor cells in colony formation assays.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 642-646 |
| Number of pages | 5 |
| Journal | Journal of Immunology |
| Volume | 169 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jul 15 2002 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
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Starnes, T., Broxmeyer, H. E., Robertson, M. J., & Hromas, R. (2002). Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis. Journal of Immunology, 169(2), 642-646. https://doi.org/10.4049/jimmunol.169.2.642