Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis

Trevor Starnes, Hal Broxmeyer, Michael Robertson, Robert Hromas

Research output: Contribution to journalArticle

189 Citations (Scopus)

Abstract

A novel cytokine termed IL-17D was cloned using nested RACE PCR. It is a secreted cytokine with homology to the IL-17 family of proteins. IL-17D is preferentially expressed in skeletal muscle, brain, adipose tissue, heart, lung, and pancreas. Treatment of endothelial cells with purified rIL-17D protein stimulated the production of IL-6, IL-8, and GM-CSF. The increased expression of IL-8 was found to be NF-κB-dependent. rIL-17D also demonstrated an inhibitory effect on hemopoiesis of myeloid progenitor cells in colony formation assays.

Original languageEnglish
Pages (from-to)642-646
Number of pages5
JournalJournal of Immunology
Volume169
Issue number2
StatePublished - Jul 15 2002

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Interleukin-27
Interleukin-17
Interleukin-8
Cytokines
Myeloid Progenitor Cells
Granulocyte-Macrophage Colony-Stimulating Factor
Adipose Tissue
Pancreas
Interleukin-6
Skeletal Muscle
Proteins
Endothelial Cells
Polymerase Chain Reaction
Lung
Brain

ASJC Scopus subject areas

  • Immunology

Cite this

Cutting edge : IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis. / Starnes, Trevor; Broxmeyer, Hal; Robertson, Michael; Hromas, Robert.

In: Journal of Immunology, Vol. 169, No. 2, 15.07.2002, p. 642-646.

Research output: Contribution to journalArticle

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