Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production

T. Starnes, Michael Robertson, G. Sledge, S. Kelich, Harikrishna Nakshatri, Hal Broxmeyer, R. Hromas

Research output: Contribution to journalArticle

274 Citations (Scopus)

Abstract

A novel secreted cytokine, termed IL-17F, was cloned using nested RACE PCR. This cytokine bears homology to IL-17. IL-17F was expressed only in activated CD4+ T cells and activated monocytes. Recombinant human IL-17F did not stimulate the proliferation of hematopoietic progenitors or the migration of mature leukocytes. However, it markedly inhibited the angiogenesis of human endothelial cells and induced endothelial cells to produce IL-2, TGF-β, and monocyte chemoattractant protein-1.

Original languageEnglish
Pages (from-to)4137-4140
Number of pages4
JournalJournal of Immunology
Volume167
Issue number8
StatePublished - Oct 15 2001

Fingerprint

Interleukin-17
Monocytes
Endothelial Cells
Cytokines
T-Lymphocytes
Chemokine CCL2
Interleukin-2
Leukocytes
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Immunology

Cite this

@article{919a8de1d97b4856a13eeb9b867edbe4,
title = "Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production",
abstract = "A novel secreted cytokine, termed IL-17F, was cloned using nested RACE PCR. This cytokine bears homology to IL-17. IL-17F was expressed only in activated CD4+ T cells and activated monocytes. Recombinant human IL-17F did not stimulate the proliferation of hematopoietic progenitors or the migration of mature leukocytes. However, it markedly inhibited the angiogenesis of human endothelial cells and induced endothelial cells to produce IL-2, TGF-β, and monocyte chemoattractant protein-1.",
author = "T. Starnes and Michael Robertson and G. Sledge and S. Kelich and Harikrishna Nakshatri and Hal Broxmeyer and R. Hromas",
year = "2001",
month = "10",
day = "15",
language = "English",
volume = "167",
pages = "4137--4140",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "8",

}

TY - JOUR

T1 - Cutting edge

T2 - IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production

AU - Starnes, T.

AU - Robertson, Michael

AU - Sledge, G.

AU - Kelich, S.

AU - Nakshatri, Harikrishna

AU - Broxmeyer, Hal

AU - Hromas, R.

PY - 2001/10/15

Y1 - 2001/10/15

N2 - A novel secreted cytokine, termed IL-17F, was cloned using nested RACE PCR. This cytokine bears homology to IL-17. IL-17F was expressed only in activated CD4+ T cells and activated monocytes. Recombinant human IL-17F did not stimulate the proliferation of hematopoietic progenitors or the migration of mature leukocytes. However, it markedly inhibited the angiogenesis of human endothelial cells and induced endothelial cells to produce IL-2, TGF-β, and monocyte chemoattractant protein-1.

AB - A novel secreted cytokine, termed IL-17F, was cloned using nested RACE PCR. This cytokine bears homology to IL-17. IL-17F was expressed only in activated CD4+ T cells and activated monocytes. Recombinant human IL-17F did not stimulate the proliferation of hematopoietic progenitors or the migration of mature leukocytes. However, it markedly inhibited the angiogenesis of human endothelial cells and induced endothelial cells to produce IL-2, TGF-β, and monocyte chemoattractant protein-1.

UR - http://www.scopus.com/inward/record.url?scp=0035887627&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035887627&partnerID=8YFLogxK

M3 - Article

C2 - 11591732

AN - SCOPUS:0035887627

VL - 167

SP - 4137

EP - 4140

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 8

ER -