Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production

T. Starnes, M. J. Robertson, G. Sledge, S. Kelich, H. Nakshatri, H. E. Broxmeyer, R. Hromas

Research output: Contribution to journalArticle

278 Scopus citations


A novel secreted cytokine, termed IL-17F, was cloned using nested RACE PCR. This cytokine bears homology to IL-17. IL-17F was expressed only in activated CD4+ T cells and activated monocytes. Recombinant human IL-17F did not stimulate the proliferation of hematopoietic progenitors or the migration of mature leukocytes. However, it markedly inhibited the angiogenesis of human endothelial cells and induced endothelial cells to produce IL-2, TGF-β, and monocyte chemoattractant protein-1.

Original languageEnglish (US)
Pages (from-to)4137-4140
Number of pages4
JournalJournal of Immunology
Issue number8
StatePublished - Oct 15 2001


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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