Cutting edge

Progesterone directly upregulates vitamin D receptor gene expression for efficient regulation of T cells by calcitriol

Shankar Thangamani, Myughoo Kim, Youngmin Son, Xinxin Huang, Heejoo Kim, Jee H. Lee, Jungyoon Cho, Benjamin Ulrich, Hal Broxmeyer, Chang H. Kim

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The two nuclear hormone receptor ligands progesterone and vitamin D (vit.D) play important roles in regulating T cells. The mechanism that connects these two hormones in regulating T cells has not been established. In this study, we report that progesterone is a novel inducer of vit.D receptor (VDR) in T cells and makes T cells highly sensitive to calcitriol. At the molecular level, the induction by progesterone is mediated by two progesterone receptor-binding elements in the intron region after the first noncoding exon of the human VDR gene. Increased expression of VDR by progesterone allows highly sensitive regulation of T cells by vit.D even when vit.D levels are suboptimal. This novel regulatory pathway allows enhanced induction of regulatory T cells but suppression of Th1 and Th17 cells by the two nuclear hormones. The results have significant ramifications in effective regulation of T cells to prevent adverse immune responses during pregnancy.

Original languageEnglish
Pages (from-to)883-886
Number of pages4
JournalJournal of Immunology
Volume194
Issue number3
DOIs
StatePublished - Feb 1 2015

Fingerprint

Calcitriol Receptors
Calcitriol
Gene Expression Regulation
Progesterone
Up-Regulation
T-Lymphocytes
Hormones
Th17 Cells
Th1 Cells
Regulatory T-Lymphocytes
Progesterone Receptors
Cytoplasmic and Nuclear Receptors
Vitamin D
Introns
Exons
Ligands
Pregnancy
Genes

ASJC Scopus subject areas

  • Immunology

Cite this

Cutting edge : Progesterone directly upregulates vitamin D receptor gene expression for efficient regulation of T cells by calcitriol. / Thangamani, Shankar; Kim, Myughoo; Son, Youngmin; Huang, Xinxin; Kim, Heejoo; Lee, Jee H.; Cho, Jungyoon; Ulrich, Benjamin; Broxmeyer, Hal; Kim, Chang H.

In: Journal of Immunology, Vol. 194, No. 3, 01.02.2015, p. 883-886.

Research output: Contribution to journalArticle

Thangamani, Shankar ; Kim, Myughoo ; Son, Youngmin ; Huang, Xinxin ; Kim, Heejoo ; Lee, Jee H. ; Cho, Jungyoon ; Ulrich, Benjamin ; Broxmeyer, Hal ; Kim, Chang H. / Cutting edge : Progesterone directly upregulates vitamin D receptor gene expression for efficient regulation of T cells by calcitriol. In: Journal of Immunology. 2015 ; Vol. 194, No. 3. pp. 883-886.
@article{ecec4195df734ee99d43a6a6f761b2b0,
title = "Cutting edge: Progesterone directly upregulates vitamin D receptor gene expression for efficient regulation of T cells by calcitriol",
abstract = "The two nuclear hormone receptor ligands progesterone and vitamin D (vit.D) play important roles in regulating T cells. The mechanism that connects these two hormones in regulating T cells has not been established. In this study, we report that progesterone is a novel inducer of vit.D receptor (VDR) in T cells and makes T cells highly sensitive to calcitriol. At the molecular level, the induction by progesterone is mediated by two progesterone receptor-binding elements in the intron region after the first noncoding exon of the human VDR gene. Increased expression of VDR by progesterone allows highly sensitive regulation of T cells by vit.D even when vit.D levels are suboptimal. This novel regulatory pathway allows enhanced induction of regulatory T cells but suppression of Th1 and Th17 cells by the two nuclear hormones. The results have significant ramifications in effective regulation of T cells to prevent adverse immune responses during pregnancy.",
author = "Shankar Thangamani and Myughoo Kim and Youngmin Son and Xinxin Huang and Heejoo Kim and Lee, {Jee H.} and Jungyoon Cho and Benjamin Ulrich and Hal Broxmeyer and Kim, {Chang H.}",
year = "2015",
month = "2",
day = "1",
doi = "10.4049/jimmunol.1401923",
language = "English",
volume = "194",
pages = "883--886",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "3",

}

TY - JOUR

T1 - Cutting edge

T2 - Progesterone directly upregulates vitamin D receptor gene expression for efficient regulation of T cells by calcitriol

AU - Thangamani, Shankar

AU - Kim, Myughoo

AU - Son, Youngmin

AU - Huang, Xinxin

AU - Kim, Heejoo

AU - Lee, Jee H.

AU - Cho, Jungyoon

AU - Ulrich, Benjamin

AU - Broxmeyer, Hal

AU - Kim, Chang H.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - The two nuclear hormone receptor ligands progesterone and vitamin D (vit.D) play important roles in regulating T cells. The mechanism that connects these two hormones in regulating T cells has not been established. In this study, we report that progesterone is a novel inducer of vit.D receptor (VDR) in T cells and makes T cells highly sensitive to calcitriol. At the molecular level, the induction by progesterone is mediated by two progesterone receptor-binding elements in the intron region after the first noncoding exon of the human VDR gene. Increased expression of VDR by progesterone allows highly sensitive regulation of T cells by vit.D even when vit.D levels are suboptimal. This novel regulatory pathway allows enhanced induction of regulatory T cells but suppression of Th1 and Th17 cells by the two nuclear hormones. The results have significant ramifications in effective regulation of T cells to prevent adverse immune responses during pregnancy.

AB - The two nuclear hormone receptor ligands progesterone and vitamin D (vit.D) play important roles in regulating T cells. The mechanism that connects these two hormones in regulating T cells has not been established. In this study, we report that progesterone is a novel inducer of vit.D receptor (VDR) in T cells and makes T cells highly sensitive to calcitriol. At the molecular level, the induction by progesterone is mediated by two progesterone receptor-binding elements in the intron region after the first noncoding exon of the human VDR gene. Increased expression of VDR by progesterone allows highly sensitive regulation of T cells by vit.D even when vit.D levels are suboptimal. This novel regulatory pathway allows enhanced induction of regulatory T cells but suppression of Th1 and Th17 cells by the two nuclear hormones. The results have significant ramifications in effective regulation of T cells to prevent adverse immune responses during pregnancy.

UR - http://www.scopus.com/inward/record.url?scp=84921494821&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921494821&partnerID=8YFLogxK

U2 - 10.4049/jimmunol.1401923

DO - 10.4049/jimmunol.1401923

M3 - Article

VL - 194

SP - 883

EP - 886

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 3

ER -