Cx43 and Mechanotransduction in Bone

Lilian I. Plotkin, Toni L. Speacht, Henry J. Donahue

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

Bone adaptation to changes in mechanical stimuli occurs by adjusting bone formation and resorption by osteoblasts and osteoclasts, to maintain optimal bone mass. Osteocytes coordinate the actions of these cells on the bone surface by sensing mechanical forces and producing cytokines that increase or prevent osteoblast and osteoclast differentiation and function. Channels formed by connexins (Cxs) and, in particular, connexin 43 (Cx43) in osteoblasts and osteocytes are central part of this mechanism to control bone mass. Cx43 hemichannels are opened by fluid flow and mediate the anti-apoptotic effect of mechanical stimulation in vitro, suggesting that Cx43 participates in mechanotransduction. However, mice lacking Cx43 in osteoblasts and/or osteocytes show an increased anabolic response to loading and decreased catabolic response to unloading. This evidence suggests that Cx43 channels expressed in osteoblastic cells are not required for the response to mechanical stimulation, but mediate the consequence of lack thereof. The molecular basis of these unexpected responses to mechanical stimulation is currently under investigation.

Original languageEnglish (US)
Pages (from-to)67-72
Number of pages6
JournalCurrent osteoporosis reports
Volume13
Issue number2
DOIs
StatePublished - 2015

Keywords

  • Bone
  • Connexin43
  • Gap junction channel
  • Hemichannel
  • Mechanotransduction
  • Osteocyte

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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