CXCL12/SDF-1 and Hematopoiesis

M. L. Capitano, H. E. Broxmeyer

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

Abstract

Regulation of hematopoietic stem and progenitor cell numbers and function as well as that of their more mature offspring within the bone marrow is critical for normal hematopoiesis. In this article, we mainly describe the role of the chemokine stromal-derived factor-1/CXCL12 and its receptor, CXCR4, in maintenance of these cell populations within the bone marrow. This includes mechanisms in which CXCL12 and CXCR4 expression is regulated under homeostatic or inflammatory conditions, and how this alters the balance between myeloid and lymphoid cell development.

Original languageEnglish (US)
Title of host publicationFunctional Cell Biology
PublisherElsevier Inc.
Pages624-631
Number of pages8
Volume3
ISBN (Electronic)9780123944474
ISBN (Print)9780123947963
DOIs
StatePublished - Jan 1 2016

Keywords

  • B cells
  • Bone marrow niche
  • CXCL12
  • Chemokines
  • Hematopoietic progenitor cells
  • Hematopoietic stem cell
  • Homing
  • Migration
  • Neutrophils
  • Retention

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Capitano, M. L., & Broxmeyer, H. E. (2016). CXCL12/SDF-1 and Hematopoiesis. In Functional Cell Biology (Vol. 3, pp. 624-631). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-394447-4.30080-3