Cyclic Change of Sphincter of Oddi Motility and Its Relationship with Small Bowel Migrating Motor Complex in Humans

Byung Moo Yoo, Jin Hong Kim, Min Jae Yang, Glen Lehman, Jae Chul Hwang, Soon Sun Kim, Joon Koo Kang, Sun Gyo Lim, Sung Jae Shin, Jae Youn Cheong, Kee Myung Lee

Research output: Contribution to journalArticle

Abstract

Background: Several animal and human studies have reported that sphincter of Oddi (SO) motility shows cyclical changes during the fasting state. However, to date, the relationship between the SO motility and the migrating motor complex (MMC) of the small bowel (SB) remains unclear in humans. Aims: We observed SO motility over a long study period and evaluated its relationship with the MMC of the SB in humans using percutaneous long-term manometry. Methods: Our study included patients with hepatolithiasis who required percutaneous transhepatic catheter placement and subsequently underwent choledochoscopy and stone removal. Long-term percutaneous transhepatic SO manometry was performed after complete stone removal. SO and SB motility were simultaneously recorded. Results: SO motility showed cyclical phasic changes with periodic high-frequency contractions similar to the MMC contractions of the SB. All high-frequency contractions of the SO coincided with phase III contractions of the MMC of the SB. The proportions of phase III contractions of SO and SB were similar, but the proportions of phase I (P = 0.001) and phase II (P = 0.002) contractions were significantly different. The mean basal SO pressure was observed to significantly increase in phase III compared to phase I (P = 0.001) and phase II (P = 0.001) contractions. Conclusions: SO motility in humans showed cyclical phasic changes closely coordinated with the MMC of the SB in a fasting state; however, the proportion of phases differed between the SO and the SB. The basal pressure significantly increased during physiological high-frequency phase III contractions of the SO.

Original languageEnglish (US)
JournalDigestive Diseases and Sciences
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Migrating Myoelectric Complexes
Sphincter of Oddi
Manometry
Fasting
Pressure

Keywords

  • Gastrointestinal motility
  • Migrating motor complex
  • Small intestine
  • Sphincter of Oddi

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Cyclic Change of Sphincter of Oddi Motility and Its Relationship with Small Bowel Migrating Motor Complex in Humans. / Yoo, Byung Moo; Kim, Jin Hong; Yang, Min Jae; Lehman, Glen; Hwang, Jae Chul; Kim, Soon Sun; Kang, Joon Koo; Lim, Sun Gyo; Shin, Sung Jae; Cheong, Jae Youn; Lee, Kee Myung.

In: Digestive Diseases and Sciences, 01.01.2018.

Research output: Contribution to journalArticle

Yoo, Byung Moo ; Kim, Jin Hong ; Yang, Min Jae ; Lehman, Glen ; Hwang, Jae Chul ; Kim, Soon Sun ; Kang, Joon Koo ; Lim, Sun Gyo ; Shin, Sung Jae ; Cheong, Jae Youn ; Lee, Kee Myung. / Cyclic Change of Sphincter of Oddi Motility and Its Relationship with Small Bowel Migrating Motor Complex in Humans. In: Digestive Diseases and Sciences. 2018.
@article{5ed2d6e34e33497abd6e179b80837e70,
title = "Cyclic Change of Sphincter of Oddi Motility and Its Relationship with Small Bowel Migrating Motor Complex in Humans",
abstract = "Background: Several animal and human studies have reported that sphincter of Oddi (SO) motility shows cyclical changes during the fasting state. However, to date, the relationship between the SO motility and the migrating motor complex (MMC) of the small bowel (SB) remains unclear in humans. Aims: We observed SO motility over a long study period and evaluated its relationship with the MMC of the SB in humans using percutaneous long-term manometry. Methods: Our study included patients with hepatolithiasis who required percutaneous transhepatic catheter placement and subsequently underwent choledochoscopy and stone removal. Long-term percutaneous transhepatic SO manometry was performed after complete stone removal. SO and SB motility were simultaneously recorded. Results: SO motility showed cyclical phasic changes with periodic high-frequency contractions similar to the MMC contractions of the SB. All high-frequency contractions of the SO coincided with phase III contractions of the MMC of the SB. The proportions of phase III contractions of SO and SB were similar, but the proportions of phase I (P = 0.001) and phase II (P = 0.002) contractions were significantly different. The mean basal SO pressure was observed to significantly increase in phase III compared to phase I (P = 0.001) and phase II (P = 0.001) contractions. Conclusions: SO motility in humans showed cyclical phasic changes closely coordinated with the MMC of the SB in a fasting state; however, the proportion of phases differed between the SO and the SB. The basal pressure significantly increased during physiological high-frequency phase III contractions of the SO.",
keywords = "Gastrointestinal motility, Migrating motor complex, Small intestine, Sphincter of Oddi",
author = "Yoo, {Byung Moo} and Kim, {Jin Hong} and Yang, {Min Jae} and Glen Lehman and Hwang, {Jae Chul} and Kim, {Soon Sun} and Kang, {Joon Koo} and Lim, {Sun Gyo} and Shin, {Sung Jae} and Cheong, {Jae Youn} and Lee, {Kee Myung}",
year = "2018",
month = "1",
day = "1",
doi = "10.1007/s10620-018-5276-0",
language = "English (US)",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer New York",

}

TY - JOUR

T1 - Cyclic Change of Sphincter of Oddi Motility and Its Relationship with Small Bowel Migrating Motor Complex in Humans

AU - Yoo, Byung Moo

AU - Kim, Jin Hong

AU - Yang, Min Jae

AU - Lehman, Glen

AU - Hwang, Jae Chul

AU - Kim, Soon Sun

AU - Kang, Joon Koo

AU - Lim, Sun Gyo

AU - Shin, Sung Jae

AU - Cheong, Jae Youn

AU - Lee, Kee Myung

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Several animal and human studies have reported that sphincter of Oddi (SO) motility shows cyclical changes during the fasting state. However, to date, the relationship between the SO motility and the migrating motor complex (MMC) of the small bowel (SB) remains unclear in humans. Aims: We observed SO motility over a long study period and evaluated its relationship with the MMC of the SB in humans using percutaneous long-term manometry. Methods: Our study included patients with hepatolithiasis who required percutaneous transhepatic catheter placement and subsequently underwent choledochoscopy and stone removal. Long-term percutaneous transhepatic SO manometry was performed after complete stone removal. SO and SB motility were simultaneously recorded. Results: SO motility showed cyclical phasic changes with periodic high-frequency contractions similar to the MMC contractions of the SB. All high-frequency contractions of the SO coincided with phase III contractions of the MMC of the SB. The proportions of phase III contractions of SO and SB were similar, but the proportions of phase I (P = 0.001) and phase II (P = 0.002) contractions were significantly different. The mean basal SO pressure was observed to significantly increase in phase III compared to phase I (P = 0.001) and phase II (P = 0.001) contractions. Conclusions: SO motility in humans showed cyclical phasic changes closely coordinated with the MMC of the SB in a fasting state; however, the proportion of phases differed between the SO and the SB. The basal pressure significantly increased during physiological high-frequency phase III contractions of the SO.

AB - Background: Several animal and human studies have reported that sphincter of Oddi (SO) motility shows cyclical changes during the fasting state. However, to date, the relationship between the SO motility and the migrating motor complex (MMC) of the small bowel (SB) remains unclear in humans. Aims: We observed SO motility over a long study period and evaluated its relationship with the MMC of the SB in humans using percutaneous long-term manometry. Methods: Our study included patients with hepatolithiasis who required percutaneous transhepatic catheter placement and subsequently underwent choledochoscopy and stone removal. Long-term percutaneous transhepatic SO manometry was performed after complete stone removal. SO and SB motility were simultaneously recorded. Results: SO motility showed cyclical phasic changes with periodic high-frequency contractions similar to the MMC contractions of the SB. All high-frequency contractions of the SO coincided with phase III contractions of the MMC of the SB. The proportions of phase III contractions of SO and SB were similar, but the proportions of phase I (P = 0.001) and phase II (P = 0.002) contractions were significantly different. The mean basal SO pressure was observed to significantly increase in phase III compared to phase I (P = 0.001) and phase II (P = 0.001) contractions. Conclusions: SO motility in humans showed cyclical phasic changes closely coordinated with the MMC of the SB in a fasting state; however, the proportion of phases differed between the SO and the SB. The basal pressure significantly increased during physiological high-frequency phase III contractions of the SO.

KW - Gastrointestinal motility

KW - Migrating motor complex

KW - Small intestine

KW - Sphincter of Oddi

UR - http://www.scopus.com/inward/record.url?scp=85053465866&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053465866&partnerID=8YFLogxK

U2 - 10.1007/s10620-018-5276-0

DO - 10.1007/s10620-018-5276-0

M3 - Article

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

ER -