Cyclin E-CDK2 protein phosphorylates plant homeodomain finger protein 8 (PHF8) and regulates its function in the cell cycle

Liping Sun, Yan Huang, Qian Wei, Xiaomei Tong, Rong Cai, Grzegorz Nalepa, Xin Ye

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Background: Cyclin E-CDK2 is a key protein kinase in the cell cycle. Results: Phosphorylation of PHF8 by cyclin E-CDK2 enhances its demethylase activity toward H3K9me2 and promotes rDNA transcription as well as S phase progression. Conclusion: Cyclin E-CDK2-dependent phosphorylation of PHF8 affects its function. Significance: We unveiled the mechanism of how cyclin E-CDK2 regulates the function of PHF8 in cell cycle regulation.

Original languageEnglish (US)
Pages (from-to)4075-4085
Number of pages11
JournalJournal of Biological Chemistry
Volume290
Issue number7
DOIs
StatePublished - Feb 13 2015

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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