Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett's esophagus to adnocarcinoma

Yan Li, John Wo, Mukunda B. Ray, Whitney Jones, Ruifeng R. Su, Susan Ellis, Robert C G Martin

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Aim: To investigate the expression of cyclooxygenase-2 (COX-2) and epithelial growth factor receptor (EGFR) throughout the progression of Barrett's esophagus (BE). Methods: COX-2 and EGFR protein expressions were detected by using immunohistochemical method. A detailed cytomorphological changes were determined. Areas of COX-2 and EGFR expression were quantified by using computer Imaging System. Results: The expressions of both COX-2 and EGFR increased along with the progression from BE to esophagus adenocarcinoma (EAC). A positive correlation was found between COX-2 expression and EGFR expression. Conclusion: COX-2 and EGFR may be cooperative in the stepwise progression from BE to EAC, thereby leading to carcinogenesis.

Original languageEnglish (US)
Pages (from-to)928-934
Number of pages7
JournalWorld Journal of Gastroenterology
Volume12
Issue number6
StatePublished - Feb 14 2006
Externally publishedYes

Fingerprint

Barrett Esophagus
Growth Factor Receptors
Cyclooxygenase 2
Up-Regulation
Computer Systems
Carcinogenesis
Proteins

Keywords

  • Barrett's esophagus
  • Carcinogenesis
  • Cycloxgenase -2 (COX-2)
  • Epithelial growth factor receptor (EGFR)

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett's esophagus to adnocarcinoma. / Li, Yan; Wo, John; Ray, Mukunda B.; Jones, Whitney; Su, Ruifeng R.; Ellis, Susan; Martin, Robert C G.

In: World Journal of Gastroenterology, Vol. 12, No. 6, 14.02.2006, p. 928-934.

Research output: Contribution to journalArticle

Li, Yan ; Wo, John ; Ray, Mukunda B. ; Jones, Whitney ; Su, Ruifeng R. ; Ellis, Susan ; Martin, Robert C G. / Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett's esophagus to adnocarcinoma. In: World Journal of Gastroenterology. 2006 ; Vol. 12, No. 6. pp. 928-934.
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