Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett's esophagus to adnocarcinoma

Yan Li, John M. Wo, Mukunda B. Ray, Whitney Jones, Ruifeng R. Su, Susan Ellis, Robert C.G. Martin

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Aim: To investigate the expression of cyclooxygenase-2 (COX-2) and epithelial growth factor receptor (EGFR) throughout the progression of Barrett's esophagus (BE). Methods: COX-2 and EGFR protein expressions were detected by using immunohistochemical method. A detailed cytomorphological changes were determined. Areas of COX-2 and EGFR expression were quantified by using computer Imaging System. Results: The expressions of both COX-2 and EGFR increased along with the progression from BE to esophagus adenocarcinoma (EAC). A positive correlation was found between COX-2 expression and EGFR expression. Conclusion: COX-2 and EGFR may be cooperative in the stepwise progression from BE to EAC, thereby leading to carcinogenesis.

Original languageEnglish (US)
Pages (from-to)928-934
Number of pages7
JournalWorld Journal of Gastroenterology
Volume12
Issue number6
DOIs
StatePublished - Feb 14 2006

Keywords

  • Barrett's esophagus
  • Carcinogenesis
  • Cycloxgenase -2 (COX-2)
  • Epithelial growth factor receptor (EGFR)

ASJC Scopus subject areas

  • Gastroenterology

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