Cyclosporine-induced acute renal dysfunction in the rat

Evidence of arteriolar vasoconstriction with preservation of tubular function

Jan English, Andrew Evan, Donald C. Houghton, William M. Bennett

Research output: Contribution to journalArticle

291 Citations (Scopus)

Abstract

Dose-related cyclosporine-induced renal dysfunction is the most frequent adverse effect noted with this exciting immunosuppressive drug. To investigate pathogenetic factors involved, we studied renal tubular function and afferent arteriolar morphology during severe experimental cyclosporine-induced reduction in glomerular filtration rate. Pair-fed male rats were given cyclosporine 50 mg/kg or olive oil vehicle alone by gavage for periods of 3-14 days. Glomerular filtration rate declined progressively, reaching a nadir of 0.18±.05 ml/min/100 g vs..86±.03 ml/min/100 g in controls at 14 days (P

Original languageEnglish (US)
Pages (from-to)135-141
Number of pages7
JournalTransplantation
Volume44
Issue number1
StatePublished - 1987

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Vasoconstriction
Cyclosporine
Glomerular Filtration Rate
Kidney
Immunosuppressive Agents
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Cyclosporine-induced acute renal dysfunction in the rat : Evidence of arteriolar vasoconstriction with preservation of tubular function. / English, Jan; Evan, Andrew; Houghton, Donald C.; Bennett, William M.

In: Transplantation, Vol. 44, No. 1, 1987, p. 135-141.

Research output: Contribution to journalArticle

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