Cystic Nephroma and Mixed Epithelial and Stromal Tumour of the Kidney: Opposite Ends of the Spectrum of the Same Entity?

Rodolfo Montironi, Roberta Mazzucchelli, Antonio Lopez-Beltran, Guido Martignoni, Liang Cheng, Francesco Montorsi, Marina Scarpelli

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Objectives: The term "renal epithelial and stromal tumour" (REST) was proposed recently to encompass the spectrum of findings observed in cystic nephroma (CN) and mixed epithelial and stromal tumour (MEST) of the kidney. Our aim was to review the broad spectrum of usual and unusual clinical and morphologic findings observed in CN and MEST. Methods: Based on Medline database searches, all aspects of CN and MEST were assessed. Results: CN and MEST have a remarkable similarity in sex predilection, age distribution, and morphologic attributes of both the epithelial and stromal components and immunohistochemical profile, albeit with variation in individual categories, with higher prevalence of stromal-to-epithelial ratio, prominent ovarian-like stroma, smaller cysts, and stromal luteinisation in MEST, and large cysts, thin septa, and low stromal-to-epithelial ratio in CN. The stromal component in both lesions expresses estrogen and progesterone receptors. Rare and unusual morphologic features, such as endometrioid, cervical, and intestinal differentiation, and luteinised ovarian-like stroma, have been described in MEST. The epithelial element occasionally shows estrogen and progesterone receptors. Rare aggressive behaviour has been reported for both neoplasms. Conclusions: Considerable overlap is apparent between the two lesions, which suggests that they may represent opposite ends of the spectrum of the same process. Even though an aggressive behaviour has been reported in very few cases, in general both neoplasms are considered benign and surgical excision is curative.

Original languageEnglish
Pages (from-to)1237-1246
Number of pages10
JournalEuropean Urology
Volume54
Issue number6
DOIs
StatePublished - Dec 2008

Fingerprint

Kidney
Neoplasms
Progesterone Receptors
Estrogen Receptors
Cysts
Luteinization
Age Distribution
Databases

Keywords

  • Cystic nephroma
  • Mixed epithelial and stromal tumour of the kidney
  • Renal epithelial and stromal tumour
  • REST

ASJC Scopus subject areas

  • Urology

Cite this

Cystic Nephroma and Mixed Epithelial and Stromal Tumour of the Kidney : Opposite Ends of the Spectrum of the Same Entity? / Montironi, Rodolfo; Mazzucchelli, Roberta; Lopez-Beltran, Antonio; Martignoni, Guido; Cheng, Liang; Montorsi, Francesco; Scarpelli, Marina.

In: European Urology, Vol. 54, No. 6, 12.2008, p. 1237-1246.

Research output: Contribution to journalArticle

Montironi, R, Mazzucchelli, R, Lopez-Beltran, A, Martignoni, G, Cheng, L, Montorsi, F & Scarpelli, M 2008, 'Cystic Nephroma and Mixed Epithelial and Stromal Tumour of the Kidney: Opposite Ends of the Spectrum of the Same Entity?', European Urology, vol. 54, no. 6, pp. 1237-1246. https://doi.org/10.1016/j.eururo.2007.10.040
Montironi, Rodolfo ; Mazzucchelli, Roberta ; Lopez-Beltran, Antonio ; Martignoni, Guido ; Cheng, Liang ; Montorsi, Francesco ; Scarpelli, Marina. / Cystic Nephroma and Mixed Epithelial and Stromal Tumour of the Kidney : Opposite Ends of the Spectrum of the Same Entity?. In: European Urology. 2008 ; Vol. 54, No. 6. pp. 1237-1246.
@article{7628b5ac1c8c4aeca5ad527277c8c330,
title = "Cystic Nephroma and Mixed Epithelial and Stromal Tumour of the Kidney: Opposite Ends of the Spectrum of the Same Entity?",
abstract = "Objectives: The term {"}renal epithelial and stromal tumour{"} (REST) was proposed recently to encompass the spectrum of findings observed in cystic nephroma (CN) and mixed epithelial and stromal tumour (MEST) of the kidney. Our aim was to review the broad spectrum of usual and unusual clinical and morphologic findings observed in CN and MEST. Methods: Based on Medline database searches, all aspects of CN and MEST were assessed. Results: CN and MEST have a remarkable similarity in sex predilection, age distribution, and morphologic attributes of both the epithelial and stromal components and immunohistochemical profile, albeit with variation in individual categories, with higher prevalence of stromal-to-epithelial ratio, prominent ovarian-like stroma, smaller cysts, and stromal luteinisation in MEST, and large cysts, thin septa, and low stromal-to-epithelial ratio in CN. The stromal component in both lesions expresses estrogen and progesterone receptors. Rare and unusual morphologic features, such as endometrioid, cervical, and intestinal differentiation, and luteinised ovarian-like stroma, have been described in MEST. The epithelial element occasionally shows estrogen and progesterone receptors. Rare aggressive behaviour has been reported for both neoplasms. Conclusions: Considerable overlap is apparent between the two lesions, which suggests that they may represent opposite ends of the spectrum of the same process. Even though an aggressive behaviour has been reported in very few cases, in general both neoplasms are considered benign and surgical excision is curative.",
keywords = "Cystic nephroma, Mixed epithelial and stromal tumour of the kidney, Renal epithelial and stromal tumour, REST",
author = "Rodolfo Montironi and Roberta Mazzucchelli and Antonio Lopez-Beltran and Guido Martignoni and Liang Cheng and Francesco Montorsi and Marina Scarpelli",
year = "2008",
month = "12",
doi = "10.1016/j.eururo.2007.10.040",
language = "English",
volume = "54",
pages = "1237--1246",
journal = "European Urology",
issn = "0302-2838",
publisher = "Elsevier",
number = "6",

}

TY - JOUR

T1 - Cystic Nephroma and Mixed Epithelial and Stromal Tumour of the Kidney

T2 - Opposite Ends of the Spectrum of the Same Entity?

AU - Montironi, Rodolfo

AU - Mazzucchelli, Roberta

AU - Lopez-Beltran, Antonio

AU - Martignoni, Guido

AU - Cheng, Liang

AU - Montorsi, Francesco

AU - Scarpelli, Marina

PY - 2008/12

Y1 - 2008/12

N2 - Objectives: The term "renal epithelial and stromal tumour" (REST) was proposed recently to encompass the spectrum of findings observed in cystic nephroma (CN) and mixed epithelial and stromal tumour (MEST) of the kidney. Our aim was to review the broad spectrum of usual and unusual clinical and morphologic findings observed in CN and MEST. Methods: Based on Medline database searches, all aspects of CN and MEST were assessed. Results: CN and MEST have a remarkable similarity in sex predilection, age distribution, and morphologic attributes of both the epithelial and stromal components and immunohistochemical profile, albeit with variation in individual categories, with higher prevalence of stromal-to-epithelial ratio, prominent ovarian-like stroma, smaller cysts, and stromal luteinisation in MEST, and large cysts, thin septa, and low stromal-to-epithelial ratio in CN. The stromal component in both lesions expresses estrogen and progesterone receptors. Rare and unusual morphologic features, such as endometrioid, cervical, and intestinal differentiation, and luteinised ovarian-like stroma, have been described in MEST. The epithelial element occasionally shows estrogen and progesterone receptors. Rare aggressive behaviour has been reported for both neoplasms. Conclusions: Considerable overlap is apparent between the two lesions, which suggests that they may represent opposite ends of the spectrum of the same process. Even though an aggressive behaviour has been reported in very few cases, in general both neoplasms are considered benign and surgical excision is curative.

AB - Objectives: The term "renal epithelial and stromal tumour" (REST) was proposed recently to encompass the spectrum of findings observed in cystic nephroma (CN) and mixed epithelial and stromal tumour (MEST) of the kidney. Our aim was to review the broad spectrum of usual and unusual clinical and morphologic findings observed in CN and MEST. Methods: Based on Medline database searches, all aspects of CN and MEST were assessed. Results: CN and MEST have a remarkable similarity in sex predilection, age distribution, and morphologic attributes of both the epithelial and stromal components and immunohistochemical profile, albeit with variation in individual categories, with higher prevalence of stromal-to-epithelial ratio, prominent ovarian-like stroma, smaller cysts, and stromal luteinisation in MEST, and large cysts, thin septa, and low stromal-to-epithelial ratio in CN. The stromal component in both lesions expresses estrogen and progesterone receptors. Rare and unusual morphologic features, such as endometrioid, cervical, and intestinal differentiation, and luteinised ovarian-like stroma, have been described in MEST. The epithelial element occasionally shows estrogen and progesterone receptors. Rare aggressive behaviour has been reported for both neoplasms. Conclusions: Considerable overlap is apparent between the two lesions, which suggests that they may represent opposite ends of the spectrum of the same process. Even though an aggressive behaviour has been reported in very few cases, in general both neoplasms are considered benign and surgical excision is curative.

KW - Cystic nephroma

KW - Mixed epithelial and stromal tumour of the kidney

KW - Renal epithelial and stromal tumour

KW - REST

UR - http://www.scopus.com/inward/record.url?scp=55649119772&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=55649119772&partnerID=8YFLogxK

U2 - 10.1016/j.eururo.2007.10.040

DO - 10.1016/j.eururo.2007.10.040

M3 - Article

C2 - 18006141

AN - SCOPUS:55649119772

VL - 54

SP - 1237

EP - 1246

JO - European Urology

JF - European Urology

SN - 0302-2838

IS - 6

ER -