Cystic partially regressed clear cell renal cell carcinoma: A potential mimic of multilocular cystic renal cell carcinoma

Sean R. Williamson, Gregory T. Maclennan, Antonio Lopez-Beltran, Rodolfo Montironi, Puay Hoon Tan, Guido Martignoni, David J. Grignon, John N. Eble, Muhammad T. Idrees, Marina Scarpelli, Liang Cheng

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Aims: To study clear cell renal cell carcinomas with predominant cystic and sclerotic components, in which a solid epithelial component precluded a diagnosis of multilocular cystic renal cell carcinoma. We designated these tumours 'cystic partially regressed clear cell renal cell carcinoma.' Methods and results: Twenty-seven tumours were studied, from patients with a median age of 58 years; the stage was most often pT1 (89%). The Fuhrman grade was 2 (48%), 1 (33%), or 3 (19%). The solid epithelial component constituted up to 30% of the tumour volume (median, 10%), whereas the cystic component constituted 15-80% (median, 65%), and the sclerotic component 10-70% (median, 20%). Thin fibrovascular septa lined by cells with clear cytoplasm were almost always present, resembling multilocular cystic renal cell carcinoma. Both zones of sclerosis and fibrovascular septa often contained inconspicuous epithelial cells. Sclerotic areas ranged in appearance from a cellular fibroblastic reaction to scar-like with a residual network of capillaries resembling haemangioma. No patient developed recurrence or metastasis. Conclusions: Cystic partially regressed clear cell renal cell carcinoma is an uncommon pattern of clear cell renal cell carcinoma, being composed of cysts with solid epithelial and sclerotic components that differentiate it from multilocular cystic renal cell carcinoma.

Original languageEnglish (US)
Pages (from-to)767-779
Number of pages13
JournalHistopathology
Volume63
Issue number6
DOIs
StatePublished - Dec 1 2013

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Keywords

  • Classification
  • Cystic partially regressed clear cell renal cell carcinoma
  • Differential diagnosis
  • Immunohistochemistry
  • Kidney
  • Multilocular cystic renal cell carcinoma
  • Neoplasia

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

Cite this

Williamson, S. R., Maclennan, G. T., Lopez-Beltran, A., Montironi, R., Tan, P. H., Martignoni, G., Grignon, D. J., Eble, J. N., Idrees, M. T., Scarpelli, M., & Cheng, L. (2013). Cystic partially regressed clear cell renal cell carcinoma: A potential mimic of multilocular cystic renal cell carcinoma. Histopathology, 63(6), 767-779. https://doi.org/10.1111/his.12239