Cystic partially regressed clear cell renal cell carcinoma

A potential mimic of multilocular cystic renal cell carcinoma

Sean R. Williamson, Gregory T. Maclennan, Antonio Lopez-Beltran, Rodolfo Montironi, Puay Hoon Tan, Guido Martignoni, David Grignon, John Eble, Muhammad Idrees, Marina Scarpelli, Liang Cheng

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Aims: To study clear cell renal cell carcinomas with predominant cystic and sclerotic components, in which a solid epithelial component precluded a diagnosis of multilocular cystic renal cell carcinoma. We designated these tumours 'cystic partially regressed clear cell renal cell carcinoma.' Methods and results: Twenty-seven tumours were studied, from patients with a median age of 58 years; the stage was most often pT1 (89%). The Fuhrman grade was 2 (48%), 1 (33%), or 3 (19%). The solid epithelial component constituted up to 30% of the tumour volume (median, 10%), whereas the cystic component constituted 15-80% (median, 65%), and the sclerotic component 10-70% (median, 20%). Thin fibrovascular septa lined by cells with clear cytoplasm were almost always present, resembling multilocular cystic renal cell carcinoma. Both zones of sclerosis and fibrovascular septa often contained inconspicuous epithelial cells. Sclerotic areas ranged in appearance from a cellular fibroblastic reaction to scar-like with a residual network of capillaries resembling haemangioma. No patient developed recurrence or metastasis. Conclusions: Cystic partially regressed clear cell renal cell carcinoma is an uncommon pattern of clear cell renal cell carcinoma, being composed of cysts with solid epithelial and sclerotic components that differentiate it from multilocular cystic renal cell carcinoma.

Original languageEnglish
Pages (from-to)767-779
Number of pages13
JournalHistopathology
Volume63
Issue number6
DOIs
StatePublished - Dec 2013

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Renal Cell Carcinoma
Capillary Hemangioma
Sclerosis
Tumor Burden
Cicatrix
Cysts
Neoplasms
Cytoplasm
Epithelial Cells
Neoplasm Metastasis
Recurrence

Keywords

  • Classification
  • Cystic partially regressed clear cell renal cell carcinoma
  • Differential diagnosis
  • Immunohistochemistry
  • Kidney
  • Multilocular cystic renal cell carcinoma
  • Neoplasia

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

Cite this

Williamson, S. R., Maclennan, G. T., Lopez-Beltran, A., Montironi, R., Tan, P. H., Martignoni, G., ... Cheng, L. (2013). Cystic partially regressed clear cell renal cell carcinoma: A potential mimic of multilocular cystic renal cell carcinoma. Histopathology, 63(6), 767-779. https://doi.org/10.1111/his.12239

Cystic partially regressed clear cell renal cell carcinoma : A potential mimic of multilocular cystic renal cell carcinoma. / Williamson, Sean R.; Maclennan, Gregory T.; Lopez-Beltran, Antonio; Montironi, Rodolfo; Tan, Puay Hoon; Martignoni, Guido; Grignon, David; Eble, John; Idrees, Muhammad; Scarpelli, Marina; Cheng, Liang.

In: Histopathology, Vol. 63, No. 6, 12.2013, p. 767-779.

Research output: Contribution to journalArticle

Williamson, SR, Maclennan, GT, Lopez-Beltran, A, Montironi, R, Tan, PH, Martignoni, G, Grignon, D, Eble, J, Idrees, M, Scarpelli, M & Cheng, L 2013, 'Cystic partially regressed clear cell renal cell carcinoma: A potential mimic of multilocular cystic renal cell carcinoma', Histopathology, vol. 63, no. 6, pp. 767-779. https://doi.org/10.1111/his.12239
Williamson SR, Maclennan GT, Lopez-Beltran A, Montironi R, Tan PH, Martignoni G et al. Cystic partially regressed clear cell renal cell carcinoma: A potential mimic of multilocular cystic renal cell carcinoma. Histopathology. 2013 Dec;63(6):767-779. https://doi.org/10.1111/his.12239
Williamson, Sean R. ; Maclennan, Gregory T. ; Lopez-Beltran, Antonio ; Montironi, Rodolfo ; Tan, Puay Hoon ; Martignoni, Guido ; Grignon, David ; Eble, John ; Idrees, Muhammad ; Scarpelli, Marina ; Cheng, Liang. / Cystic partially regressed clear cell renal cell carcinoma : A potential mimic of multilocular cystic renal cell carcinoma. In: Histopathology. 2013 ; Vol. 63, No. 6. pp. 767-779.
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abstract = "Aims: To study clear cell renal cell carcinomas with predominant cystic and sclerotic components, in which a solid epithelial component precluded a diagnosis of multilocular cystic renal cell carcinoma. We designated these tumours 'cystic partially regressed clear cell renal cell carcinoma.' Methods and results: Twenty-seven tumours were studied, from patients with a median age of 58 years; the stage was most often pT1 (89{\%}). The Fuhrman grade was 2 (48{\%}), 1 (33{\%}), or 3 (19{\%}). The solid epithelial component constituted up to 30{\%} of the tumour volume (median, 10{\%}), whereas the cystic component constituted 15-80{\%} (median, 65{\%}), and the sclerotic component 10-70{\%} (median, 20{\%}). Thin fibrovascular septa lined by cells with clear cytoplasm were almost always present, resembling multilocular cystic renal cell carcinoma. Both zones of sclerosis and fibrovascular septa often contained inconspicuous epithelial cells. Sclerotic areas ranged in appearance from a cellular fibroblastic reaction to scar-like with a residual network of capillaries resembling haemangioma. No patient developed recurrence or metastasis. Conclusions: Cystic partially regressed clear cell renal cell carcinoma is an uncommon pattern of clear cell renal cell carcinoma, being composed of cysts with solid epithelial and sclerotic components that differentiate it from multilocular cystic renal cell carcinoma.",
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